Use of antidepressant medications in relation to the incidence of breast cancer

Although associations have been reported between antidepressant use and risk of breast cancer, the findings have been inconsistent. We conducted a population-based case–control study among women enrolled in Group Health Cooperative (GHC), a health maintenance organization in Washington State. Women...

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Bibliographic Details
Published in:British journal of cancer 2006-04, Vol.94 (7), p.1071-1078
Main Authors: Fulton-Kehoe, D, Rossing, M A, Rutter, C, Mandelson, M T, Weiss, N S
Format: Article
Language:English
Subjects:
Adult
Aged
Antidepressive Agents - adverse effects
Antidepressive Agents - therapeutic use
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - epidemiology
Cancer Research
Case-Control Studies
Databases, Factual
Drug Resistance
Epidemiology
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Middle Aged
Molecular Medicine
Oncology
Risk Factors
Tumors
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Summary:Although associations have been reported between antidepressant use and risk of breast cancer, the findings have been inconsistent. We conducted a population-based case–control study among women enrolled in Group Health Cooperative (GHC), a health maintenance organization in Washington State. Women with a first primary breast cancer diagnosed between 1990 and 2001 were identified ( N =2904) and five controls were selected for each case ( N =14396). Information on antidepressant use was ascertained through the GHC pharmacy database and on breast cancer risk factors and screening mammograms from GHC records. Prior to one year before diagnosis of breast cancer, about 20% of cases and controls had used tricyclic antidepressants (adjusted odds ratio=1.06, 95% CI 0.94–1.19) and 6% of each group had used selective serotonin reuptake inhibitors (OR=0.98, 95% CI 0.80–1.18). There also were no differences between cases and controls with regard to the number of prescriptions filled or the timing of use. Taken as a whole, the results from this and other studies to date do not indicate an altered risk of breast cancer associated with the use of antidepressants overall, by class, or for individual antidepressants.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6603017