Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma

We evaluated the expression and amplification of cyclin L1 ( CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25–28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tum...

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Published in:British journal of cancer 2006-04, Vol.94 (7), p.1041-1044
Main Authors: Muller, D, Millon, R, Théobald, S, Hussenet, T, Wasylyk, B, du Manoir, S, Abecassis, J
Format: Article
Language:English
Subjects:
Biochemistry, Molecular Biology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Carcinoma, Squamous Cell
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Case-Control Studies
Chromosomes
Cyclins
Cyclins - biosynthesis
Cyclins - genetics
Disease Progression
Drug Resistance
Epidemiology
Gene Amplification
Gene expression
Gene Expression Profiling
Head and Neck Neoplasms
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - pathology
Humans
Life Sciences
Medical research
Molecular biology
Molecular Medicine
molecular-diagnostics
Oncology
Polymerase Chain Reaction
Proteins
RNA Splicing
Short Communication
Tumors
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description We evaluated the expression and amplification of cyclin L1 ( CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25–28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumours (26%) with no relationships to the clinico-pathological parameters. The Cyclin L1 antibody we developed labels nuclear speckles in tumour cells compatible with a role for CCNL1 in RNA splicing.
doi_str_mv 10.1038/sj.bjc.6603036
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subjects Biochemistry, Molecular Biology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Carcinoma, Squamous Cell
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Case-Control Studies
Chromosomes
Cyclins
Cyclins - biosynthesis
Cyclins - genetics
Disease Progression
Drug Resistance
Epidemiology
Gene Amplification
Gene expression
Gene Expression Profiling
Head and Neck Neoplasms
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - pathology
Humans
Life Sciences
Medical research
Molecular biology
Molecular Medicine
molecular-diagnostics
Oncology
Polymerase Chain Reaction
Proteins
RNA Splicing
Short Communication
Tumors
title Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma
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