The presence of a systemic inflammatory response predicts poorer survival in patients receiving adjuvant 5-FU chemotherapy following potentially curative resection for colorectal cancer

There is increasing evidence that the presence of a systemic inflammatory response plays an important role in survival following curative resection for colorectal cancer. The present study evaluated the relationship between C-reactive protein concentrations and survival in a cohort of patients recei...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2006-06, Vol.94 (12), p.1833-1836
Main Authors: Crozier, J E M, McKee, R F, McArdle, C S, Angerson, W J, Anderson, J H, Horgan, P G, McMillan, D C
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adenocarcinoma - mortality
Adenocarcinoma - surgery
Aged
Antimetabolites, Antineoplastic - therapeutic use
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
C-Reactive Protein - analysis
Cancer Research
Chemotherapy
Chemotherapy, Adjuvant
Colorectal cancer
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - mortality
Colorectal Neoplasms - surgery
Digestive System Surgical Procedures
Drug Resistance
Epidemiology
Female
Fluorouracil - therapeutic use
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Inflammation - physiopathology
Male
Medical prognosis
Medical research
Medical sciences
Middle Aged
Molecular Medicine
Oncology
Prognosis
Proteins
Radiation therapy
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Survival Analysis
Survival Rate
Translational Therapeutics
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There is increasing evidence that the presence of a systemic inflammatory response plays an important role in survival following curative resection for colorectal cancer. The present study evaluated the relationship between C-reactive protein concentrations and survival in a cohort of patients receiving adjuvant 5-fluorouracil (5-FU) chemotherapy following potentially curative resection for colorectal cancer. In all, 222 patients undergoing potentially curative resection for colorectal cancer were studied. Of these, 50 patients received adjuvant 5-FU-based chemotherapy. Circulating concentrations of C-reactive protein were measured prior to surgery. The minimum follow-up was 15 months; the median follow-up of the survivors was 38 months. During this period 61 patients died, 32 patients of their cancer and 29 of intercurrent disease. In those patients who did not receive adjuvant chemotherapy, age ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6603185