Characterisation and protein expression profiling of annexins in colorectal cancer

The annexins are family of calcium-regulated phospholipid-binding proteins with diverse roles in cell biology. Individual annexins have been implicated in tumour development and progression, and in this investigation a range of annexins have been studied in colorectal cancer. Annexins A1, A2, A4 and...

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Bibliographic Details
Published in:British journal of cancer 2008-01, Vol.98 (2), p.426-433
Main Authors: Duncan, R, Carpenter, B, Main, L C, Telfer, C, Murray, G I
Format: Article
Language:English
Subjects:
Adenocarcinoma - metabolism
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Annexins - metabolism
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Breast cancer
Cancer Research
Cell division
Cluster analysis
Colorectal cancer
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Disease Progression
Drug Resistance
Epidemiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical prognosis
Medical research
Medical sciences
Metastasis
Middle Aged
Molecular Diagnostics
Molecular Medicine
Oncology
Pathology
Prostate cancer
Protein Array Analysis
Protein expression
Proteins
Proteomics
Sarcoma
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Tissue Array Analysis
Tumorigenesis
Tumors
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Summary:The annexins are family of calcium-regulated phospholipid-binding proteins with diverse roles in cell biology. Individual annexins have been implicated in tumour development and progression, and in this investigation a range of annexins have been studied in colorectal cancer. Annexins A1, A2, A4 and A11 were identified by comparative proteomic analysis to be overexpressed in colorectal cancer. Annexins A1, A2, A4 and A11 were further studied by immunohistochemistry with a colorectal cancer tissue microarray containing primary and metastatic colorectal cancer and also normal colon. There was significant increase in expression in annexins A1 ( P =0.01), A2 ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604128