Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder

Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro , a...

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Bibliographic Details
Published in:British journal of cancer 2005-05, Vol.92 (10), p.1906-1914
Main Authors: Cheng, H-L, Liu, H-S, Lin, Y-J, Chen, H H-W, Hsu, P-Y, Chang, T-Y, Ho, C-L, Tzai, T-S, Chow, N-H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - analysis
Biomedical and Life Sciences
Biomedicine
Bladder cancer
Cancer Research
Cancer therapies
Carcinoma, Transitional Cell - genetics
Carcinoma, Transitional Cell - pathology
Clinical significance
Cohort Studies
Drug Resistance
Epidemiology
Gene Expression Profiling
Hepatocyte Growth Factor
Humans
Immunohistochemistry
Kinases
Ligands
Macrophages
Medical research
Medical sciences
Molecular Diagnostics
Molecular Medicine
Nephrology. Urinary tract diseases
Oncology
Polymerase Chain Reaction
Prognosis
Proteins
Proto-Oncogene Proteins c-met - biosynthesis
Proto-Oncogene Proteins c-met - genetics
Receptor Protein-Tyrosine Kinases - biosynthesis
Receptor Protein-Tyrosine Kinases - genetics
Survival Analysis
Tumors
Tumors of the urinary system
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - pathology
Urinary tract. Prostate gland
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Summary:Recepteur d'Origine Nantais (RON) is a distinct receptor tyrosine kinase in the c-met proto-oncogene family. We examined the mutational and expression patterns of RON in eight human uroepithelial cell lines. Biological effects of RON overexpression on cancer cells were investigated in vitro , and the prognostic significance of RON and/or c-met protein (MET) expression was analysed in a bladder cancer cohort ( n =183). There was no evidence of mutation in the kinase domain of RON. Overexpression of RON using an inducible Tet-off system induced increased cell proliferation, motility, and antiapoptosis. Immunohistochemical analysis showed that RON was overexpressed in 60 cases (32.8%) of primary tumours, with 14 (23.3%) showing a high level of expression. Recepteur d'Origine Nantais expression was positively associated with histological grading, larger size, nonpapillary contour, and tumour stage (all P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6602593