The metastasis associated protein S100A4: role in tumour progression and metastasis

The metastasis associated protein S100A4 is a small calcium binding protein that is associated with metastatic tumors and appears to be a molecular marker for clinical prognosis. Below we discuss its biochemical properties and possible cellular functions in metastasis including cell motility, invasi...

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Bibliographic Details
Published in:British journal of cancer 2005-06, Vol.92 (11), p.1955-1958
Main Authors: Helfman, D M, Kim, E J, Lukanidin, E, Grigorian, M
Format: Article
Language:English
Subjects:
Apoptosis
Biology
Breast cancer
Cancer research
Cell Movement
Cell Transformation, Neoplastic
Chemotherapy
Disease Progression
Gene Expression Regulation, Neoplastic
Humans
Medical prognosis
Medical research
Metastasis
Minireview
Motility
Neoplasm Invasiveness
Neoplasm Metastasis - genetics
Neoplasm Metastasis - physiopathology
Neoplasms - genetics
Neoplasms - pathology
Neovascularization, Pathologic
Phenotype
Prognosis
Proteins
S100 Calcium-Binding Protein A4
S100 Proteins - genetics
S100 Proteins - physiology
Transgenic animals
Tumors
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Summary:The metastasis associated protein S100A4 is a small calcium binding protein that is associated with metastatic tumors and appears to be a molecular marker for clinical prognosis. Below we discuss its biochemical properties and possible cellular functions in metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6602613