The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

There is increasing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of common solid tumours. The aim of the present study was to examine the relationship between tumour T-lymphocyte subset infiltration, the systemic inflammatory res...

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Bibliographic Details
Published in:British journal of cancer 2005-02, Vol.92 (4), p.651-654
Main Authors: Canna, K, McArdle, P A, McMillan, D C, McNicol, A-M, Smith, G W, McKee, R F, McArdle, C S
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
C-Reactive Protein - metabolism
Cancer Research
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Clinical Study
Colorectal cancer
Colorectal Neoplasms - blood
Colorectal Neoplasms - immunology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Drug Resistance
Epidemiology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Lymphatic Metastasis
Lymphocytes
Male
Medical research
Medical sciences
Middle Aged
Molecular Medicine
Neoplasm Invasiveness
Oncology
Predictive Value of Tests
Proteins
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Survival Analysis
Systemic Inflammatory Response Syndrome - blood
Systemic Inflammatory Response Syndrome - immunology
Systemic Inflammatory Response Syndrome - mortality
T-Lymphocytes
Tumors
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Summary:There is increasing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of common solid tumours. The aim of the present study was to examine the relationship between tumour T-lymphocyte subset infiltration, the systemic inflammatory response and cancer-specific survival in patients with colorectal cancer. In all, 147 patients undergoing potentially curative resection for colorectal cancer were studied. Circulating concentrations of C-reactive protein were measured prior to surgery. CD4+ and CD8+ T-lymphocyte infiltration of the tumour was assessed using immunohistochemistry and a point counting technique. When patients were grouped according to the percentage tumour volume of CD4+ T-lymphocytes, there was no difference in terms of age, sex, tumour site, stage and tumour characteristics. However, there was an inverse relationship between percentage tumour CD4+ T-lymphocytes and C-reactive protein ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6602419