Conservative treatment followed by chemotherapy with doxorubicin and ifosfamide for cervical sarcoma botryoides in young females

• Published in: British Journal of Cancer 1999-05, Vol.80 (3-4), p.403-406
• Main Authors: Zanetta, G, Rota, S M, Lissoni, A, Bratina, G, Mangioni, C
• Format: Article
• Language: English
• Subjects: Adult; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Chemotherapy, Adjuvant; Combined Modality Therapy; Combined treatments (chemotherapy of immunotherapy associated with an other treatment); Doxorubicin - administration & dosage; Drug Resistance; Epidemiology; Female; Humans; Ifosfamide - administration & dosage; Medical sciences; Molecular Medicine; Oncology; Pharmacology. Drug treatments; Regular; regular-article; Rhabdomyosarcoma, Embryonal - drug therapy; Rhabdomyosarcoma, Embryonal - pathology; Rhabdomyosarcoma, Embryonal - surgery; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - radiotherapy; Uterine Cervical Neoplasms - surgery
• ISSN: 0007-0920; 1476-5381; 1532-1827
• DOI: 10.1038/sj.bjc.6690370

Summary Sarcoma botryoides of the cervix is an extremely rare tumour and seems to be associated with a better prognosis than its vaginal counterpart. Recent studies have suggested that it is possible to limit surgery to local excision in stage I cases. We report three cases of young subjects treated successfully with polypectomy or diathermy loop excision followed by adjuvant chemotherapy. One patient had a local recurrence which was treated with further local excision. All subjects remain alive without evidence of recurrence and with normal menstrual function 36, 38 and 38 months following initial diagnosis. A conservative surgical approach to early cervical sarcoma botryoides is possible. The efficacy of adjuvant chemotherapy and the regimen of choice still need to be investigated.