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Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas
Summary Expression of CDX2 , a caudal -related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to Cdx2 develop multiple intestinal adenomatous polyps. To clarify the role of CDX2 in colorectal carcinogenesis, we determined its genomic structure, an...
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| Published in: | British journal of cancer 1999-02, Vol.79 (3), p.440-444 |
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| Main Authors: | , , |
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| Language: | English |
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| container_end_page | 444 |
| container_issue | 3 |
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| container_title | British journal of cancer |
| container_volume | 79 |
| creator | Yagi, O K Akiyama, Y Yuasa, Y |
| description | Summary
Expression of
CDX2
, a
caudal
-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to
Cdx2
develop multiple intestinal adenomatous polyps. To clarify the role of
CDX2
in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of
CDX2
in 49 sporadic colorectal carcinomas and ten hereditary non-polyposis colorectal cancers (HNPCC) without microsatellite instability. None of them exhibited a mutation. We further examined 19 HNPCC carcinomas with microsatellite instability for mutations in a (G)7 repeat site within
CDX2
. One of them (5.3%) exhibited one G insertion. Loss of heterozygosity was observed in 2 of the 20 (10%) informative sporadic carcinomas, and in one of the three (33.3%) informative HNPCC cancers. These data indicate that
CDX2
may play only a minor role in colorectal carcinogenesis. |
| doi_str_mv | 10.1038/sj.bjc.6690068 |
| format | article |
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Expression of
CDX2
, a
caudal
-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to
Cdx2
develop multiple intestinal adenomatous polyps. To clarify the role of
CDX2
in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of
CDX2
in 49 sporadic colorectal carcinomas and ten hereditary non-polyposis colorectal cancers (HNPCC) without microsatellite instability. None of them exhibited a mutation. We further examined 19 HNPCC carcinomas with microsatellite instability for mutations in a (G)7 repeat site within
CDX2
. One of them (5.3%) exhibited one G insertion. Loss of heterozygosity was observed in 2 of the 20 (10%) informative sporadic carcinomas, and in one of the three (33.3%) informative HNPCC cancers. These data indicate that
CDX2
may play only a minor role in colorectal carcinogenesis.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6690068</identifier><identifier>PMID: 10027310</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoma - genetics ; Cell Transformation, Neoplastic - genetics ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis - genetics ; DNA Mutational Analysis ; DNA, Neoplasm - analysis ; DNA, Neoplasm - genetics ; Drug Resistance ; Epidemiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins - genetics ; Humans ; Loss of Heterozygosity ; Medical sciences ; Mice ; Microsatellite Repeats - genetics ; Molecular Medicine ; Molecular Sequence Data ; Oncology ; Regular ; regular-article ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>British journal of cancer, 1999-02, Vol.79 (3), p.440-444</ispartof><rights>The Author(s) 1999</rights><rights>1999 INIST-CNRS</rights><rights>Copyright © 1999 Cancer Research Campaign 1999 Cancer Research Campaign</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-8d0d4d5b1a33eee07f2ada93650e5711aee85a7a9faed923ddb5c35905c55dc33</citedby><cites>FETCH-LOGICAL-c552t-8d0d4d5b1a33eee07f2ada93650e5711aee85a7a9faed923ddb5c35905c55dc33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362430/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362430/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1665670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10027310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yagi, O K</creatorcontrib><creatorcontrib>Akiyama, Y</creatorcontrib><creatorcontrib>Yuasa, Y</creatorcontrib><title>Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Summary
Expression of
CDX2
, a
caudal
-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to
Cdx2
develop multiple intestinal adenomatous polyps. To clarify the role of
CDX2
in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of
CDX2
in 49 sporadic colorectal carcinomas and ten hereditary non-polyposis colorectal cancers (HNPCC) without microsatellite instability. None of them exhibited a mutation. We further examined 19 HNPCC carcinomas with microsatellite instability for mutations in a (G)7 repeat site within
CDX2
. One of them (5.3%) exhibited one G insertion. Loss of heterozygosity was observed in 2 of the 20 (10%) informative sporadic carcinomas, and in one of the three (33.3%) informative HNPCC cancers. These data indicate that
CDX2
may play only a minor role in colorectal carcinogenesis.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma - genetics</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms, Hereditary Nonpolyposis - genetics</subject><subject>DNA Mutational Analysis</subject><subject>DNA, Neoplasm - analysis</subject><subject>DNA, Neoplasm - genetics</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Homeodomain Proteins - genetics</subject><subject>Humans</subject><subject>Loss of Heterozygosity</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microsatellite Repeats - genetics</subject><subject>Molecular Medicine</subject><subject>Molecular Sequence Data</subject><subject>Oncology</subject><subject>Regular</subject><subject>regular-article</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp1kUFv1DAQhS0EotvClSPyAXHLdmyv4-SChBYoSJXgABI3a2JPtokSu9gJgn-Pq13RcuA0Gs03b0bvMfZCwFaAai7zuO1Gt63rFqBuHrGN0EpWopHmMdsAgKmglXDGznMeS9tCY56yMwEgjRKwYV-uKMR5cDwvaXXLmohj8BynhRIuQwyZx57fxJliF3_xAwXi-3ffJR8Cd3GKidyCE3eY3FCEMD9jT3qcMj0_1Qv27cP7r_uP1fXnq0_7t9eV01ouVePB77zuBCpFRGB6iR5bVWsgbYRAokajwbZH8q1U3nfaKd2CLvveKXXB3hx1b9duJu8oLAkne5uGGdNvG3Gw_07CcGMP8aeVqpY7BUXg9UkgxR8r5cXOQ3Y0TRgortkKI5Vpml0Bt0fQpZhzov7vEQH2LgSbR1tCsKcQysLLh689wI-uF-DVCcDscOoTBjfke66udW3usMsjlsskHCjZMa4pFFf_d_kPBHmiPA</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>Yagi, O K</creator><creator>Akiyama, Y</creator><creator>Yuasa, Y</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>19990201</creationdate><title>Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas</title><author>Yagi, O K ; Akiyama, Y ; Yuasa, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-8d0d4d5b1a33eee07f2ada93650e5711aee85a7a9faed923ddb5c35905c55dc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma - genetics</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - genetics</topic><topic>DNA Mutational Analysis</topic><topic>DNA, Neoplasm - analysis</topic><topic>DNA, Neoplasm - genetics</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Homeodomain Proteins - genetics</topic><topic>Humans</topic><topic>Loss of Heterozygosity</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microsatellite Repeats - genetics</topic><topic>Molecular Medicine</topic><topic>Molecular Sequence Data</topic><topic>Oncology</topic><topic>Regular</topic><topic>regular-article</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yagi, O K</creatorcontrib><creatorcontrib>Akiyama, Y</creatorcontrib><creatorcontrib>Yuasa, Y</creatorcontrib><collection>Springer Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yagi, O K</au><au>Akiyama, Y</au><au>Yuasa, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1999-02-01</date><risdate>1999</risdate><volume>79</volume><issue>3</issue><spage>440</spage><epage>444</epage><pages>440-444</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Summary
Expression of
CDX2
, a
caudal
-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to
Cdx2
develop multiple intestinal adenomatous polyps. To clarify the role of
CDX2
in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of
CDX2
in 49 sporadic colorectal carcinomas and ten hereditary non-polyposis colorectal cancers (HNPCC) without microsatellite instability. None of them exhibited a mutation. We further examined 19 HNPCC carcinomas with microsatellite instability for mutations in a (G)7 repeat site within
CDX2
. One of them (5.3%) exhibited one G insertion. Loss of heterozygosity was observed in 2 of the 20 (10%) informative sporadic carcinomas, and in one of the three (33.3%) informative HNPCC cancers. These data indicate that
CDX2
may play only a minor role in colorectal carcinogenesis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>10027310</pmid><doi>10.1038/sj.bjc.6690068</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 1999-02, Vol.79 (3), p.440-444 |
| issn | 0007-0920 1532-1827 |
| language | eng |
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| source | PubMed Central |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma - genetics Cell Transformation, Neoplastic - genetics Colorectal Neoplasms - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA Mutational Analysis DNA, Neoplasm - analysis DNA, Neoplasm - genetics Drug Resistance Epidemiology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Homeodomain Proteins - genetics Humans Loss of Heterozygosity Medical sciences Mice Microsatellite Repeats - genetics Molecular Medicine Molecular Sequence Data Oncology Regular regular-article Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas |
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