A Clinical Study of Photodynamic Therapy for Superficial Esophageal Carcinoma by YAG-OPO Laser

A cooperative clinical study of photodynamic therapy (PDT) for superficial esophageal carcinoma was conducted at 6 medical institution. PHE (2mg/kg) with high tumor affinity was used as the oncotropic compound. The light source was a pulse wave YAGOPO laser with high penetration into the tissue. Irr...

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Bibliographic Details
Published in:Diagnostic and Therapeutic Endoscopy 1998, Vol.1998 (4), p.173-176
Main Authors: Yoshida, K, Suzuki, S, Mimura, S, Narahara, H, Tanimura, H, Nagai, Y, Isono, K, Kozu, T, Fukutomi, H, Nakahara, A, Kashimura, H, Hirashima, T, Murata, Y, Ide, H, Kato, H
Format: Article
Language:English
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Summary:A cooperative clinical study of photodynamic therapy (PDT) for superficial esophageal carcinoma was conducted at 6 medical institution. PHE (2mg/kg) with high tumor affinity was used as the oncotropic compound. The light source was a pulse wave YAGOPO laser with high penetration into the tissue. Irradiation was performed at an energy density of 60-180J/cm^2 48-72h after PHE administration. Eight lesions in 6 patients were treated. All were type 0-II superficial carcinomas. The depth of invasion was EPMM for 6 lesions and SM for 2 lesions. A complete response (CR) was achieved in all patients after one session of PDT. Five adverse events, including anemia and fever, were reported by 4 patients, but all were WHO grade 2 or lower and transient. PDT using PHE and YAG-OPO laser was therefore considered effective as a curative therapy for superficial esophageal carcinoma.
ISSN:1070-3608
1029-0516
DOI:10.1155/DTE.4.173