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Ejaculation in testicular cancer patients after post-chemotherapy retroperitoneal lymph node dissection
The purpose of this study was to evaluate fertility after different types of post-chemotherapy retroperitoneal lymph node dissection (RPLND). During 1980–1994, 192 patients with metastatic testicular cancer underwent post-chemotherapy RPLND with a gradual shift from modified bilateral template RPLND...
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Published in: | British Journal of Cancer 1999-04, Vol.80 (1-2), p.249-255 |
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description | The purpose of this study was to evaluate fertility after different types of post-chemotherapy retroperitoneal lymph node dissection (RPLND). During 1980–1994, 192 patients with metastatic testicular cancer underwent post-chemotherapy RPLND with a gradual shift from modified bilateral template RPLND to nerve-sparing RPLND. Modified bilateral template RPLND was done in 92% of the patients operated during 1980–1984 as compared to 16% during 1989–1994. Pre- and post-treatment fertility was assessed by microscopic sperm analysis, determination of serum FSH and information on ejaculation and paternity. There was no significant difference of the survival rates between the three treatment periods. Antegrade ejaculation was preserved in 11% of the patients after modified bilateral template RPLND as compared to 89% after the nerve-sparing operation technique. The median ejaculatory volume decreased post-operatively, serum FSH increased and sperm density remained unchanged. Fifty-six patients attempted fatherhood after their treatment, and 27 fathered at least one child after an observation-time of 55 months, nine of them by assisted fertilization. Patients with initially advanced testicular cancer but limited residual retroperitoneal masses after induction chemotherapy can safely undergo limited post-chemotherapy RPLND as a part of multimodality treatment. After nerve-sparing RPLND antegrade ejaculation is preserved in 89% of the patients though the ejaculatory volume decreases after RPLND. Post-treatment fatherhood can be achieved in at least 50% of the patients attempting paternity. |
doi_str_mv | 10.1038/sj.bjc.6690347 |
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During 1980–1994, 192 patients with metastatic testicular cancer underwent post-chemotherapy RPLND with a gradual shift from modified bilateral template RPLND to nerve-sparing RPLND. Modified bilateral template RPLND was done in 92% of the patients operated during 1980–1984 as compared to 16% during 1989–1994. Pre- and post-treatment fertility was assessed by microscopic sperm analysis, determination of serum FSH and information on ejaculation and paternity. There was no significant difference of the survival rates between the three treatment periods. Antegrade ejaculation was preserved in 11% of the patients after modified bilateral template RPLND as compared to 89% after the nerve-sparing operation technique. The median ejaculatory volume decreased post-operatively, serum FSH increased and sperm density remained unchanged. Fifty-six patients attempted fatherhood after their treatment, and 27 fathered at least one child after an observation-time of 55 months, nine of them by assisted fertilization. Patients with initially advanced testicular cancer but limited residual retroperitoneal masses after induction chemotherapy can safely undergo limited post-chemotherapy RPLND as a part of multimodality treatment. After nerve-sparing RPLND antegrade ejaculation is preserved in 89% of the patients though the ejaculatory volume decreases after RPLND. Post-treatment fatherhood can be achieved in at least 50% of the patients attempting paternity.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1476-5381</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6690347</identifier><identifier>PMID: 10390004</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adolescent ; Adult ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Combined Modality Therapy ; Drug Resistance ; Ejaculation ; Epidemiology ; Gynecology. Andrology. Obstetrics ; Humans ; Lymph Node Excision ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Molecular Medicine ; Neoplasm Metastasis ; Oncology ; Orchiectomy ; Regular ; regular-article ; Testicular Neoplasms - drug therapy ; Testicular Neoplasms - pathology ; Testicular Neoplasms - surgery ; Treatment Outcome ; Tumors</subject><ispartof>British Journal of Cancer, 1999-04, Vol.80 (1-2), p.249-255</ispartof><rights>The Author(s) 1999</rights><rights>1999 INIST-CNRS</rights><rights>Copyright © 1999 Cancer Research Campaign 1999 Cancer Research Campaign</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-f9bcbabc4c99187b5fb6e615ba866d83895026cd5d320b34a6663d5fb3fb72d63</citedby><cites>FETCH-LOGICAL-c477t-f9bcbabc4c99187b5fb6e615ba866d83895026cd5d320b34a6663d5fb3fb72d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363017/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363017/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1788620$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10390004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacobsen, K D</creatorcontrib><creatorcontrib>Ous, S</creatorcontrib><creatorcontrib>Wæhre, H</creatorcontrib><creatorcontrib>Trasti, H</creatorcontrib><creatorcontrib>Stenwig, A E</creatorcontrib><creatorcontrib>Lien, H H</creatorcontrib><creatorcontrib>Aass, N</creatorcontrib><creatorcontrib>Fosså, S D</creatorcontrib><title>Ejaculation in testicular cancer patients after post-chemotherapy retroperitoneal lymph node dissection</title><title>British Journal of Cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>The purpose of this study was to evaluate fertility after different types of post-chemotherapy retroperitoneal lymph node dissection (RPLND). During 1980–1994, 192 patients with metastatic testicular cancer underwent post-chemotherapy RPLND with a gradual shift from modified bilateral template RPLND to nerve-sparing RPLND. Modified bilateral template RPLND was done in 92% of the patients operated during 1980–1984 as compared to 16% during 1989–1994. Pre- and post-treatment fertility was assessed by microscopic sperm analysis, determination of serum FSH and information on ejaculation and paternity. There was no significant difference of the survival rates between the three treatment periods. Antegrade ejaculation was preserved in 11% of the patients after modified bilateral template RPLND as compared to 89% after the nerve-sparing operation technique. The median ejaculatory volume decreased post-operatively, serum FSH increased and sperm density remained unchanged. Fifty-six patients attempted fatherhood after their treatment, and 27 fathered at least one child after an observation-time of 55 months, nine of them by assisted fertilization. Patients with initially advanced testicular cancer but limited residual retroperitoneal masses after induction chemotherapy can safely undergo limited post-chemotherapy RPLND as a part of multimodality treatment. After nerve-sparing RPLND antegrade ejaculation is preserved in 89% of the patients though the ejaculatory volume decreases after RPLND. Post-treatment fatherhood can be achieved in at least 50% of the patients attempting paternity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Combined Modality Therapy</subject><subject>Drug Resistance</subject><subject>Ejaculation</subject><subject>Epidemiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasm Metastasis</subject><subject>Oncology</subject><subject>Orchiectomy</subject><subject>Regular</subject><subject>regular-article</subject><subject>Testicular Neoplasms - drug therapy</subject><subject>Testicular Neoplasms - pathology</subject><subject>Testicular Neoplasms - surgery</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1476-5381</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp1kb2P1DAQxS0E4paDlg7kAtFlz4kTx2mQ0On4kE6igdqyncmuo8QOtoO0_z2zynIcBZU1fr95M5pHyOuS7UvG5U0a92a0eyE6xuv2CdmVdSuKhsvyKdkxxtqCdRW7Ii9SGhlDsW2ekyts7VCsd-RwN2q7Tjq74KnzNEPK7vwRqdXeQqQLauBzonrI5zKkXNgjzCEfIerlRCPkGBaILgcPeqLTaV6O1IceaO9SAnv2fkmeDXpK8OryXpMfn-6-334p7r99_nr78b6wuFouhs5Yo42tbdeVsjXNYASIsjFaCtFLLruGVcL2Tc8rZnithRC8R4oPpq16wa_Jh813Wc0MvcXNo57UEt2s40kF7dS_indHdQi_VMUFZ2WLBu8vBjH8XPEaanbJwjRpD2FNSnRS4PVqBPcbaGNIKcLwMKRk6pyNSqPCbNQlG2x4-3i1R_gWBgLvLoBOVk9DxABc-su1UoqKIXazYQkVf4CoxrBGj1f9_-Q3W4fXeY3w4PhH_w252LXk</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Jacobsen, K D</creator><creator>Ous, S</creator><creator>Wæhre, H</creator><creator>Trasti, H</creator><creator>Stenwig, A E</creator><creator>Lien, H H</creator><creator>Aass, N</creator><creator>Fosså, S D</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990401</creationdate><title>Ejaculation in testicular cancer patients after post-chemotherapy retroperitoneal lymph node dissection</title><author>Jacobsen, K D ; Ous, S ; Wæhre, H ; Trasti, H ; Stenwig, A E ; Lien, H H ; Aass, N ; Fosså, S D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-f9bcbabc4c99187b5fb6e615ba866d83895026cd5d320b34a6663d5fb3fb72d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Combined Modality Therapy</topic><topic>Drug Resistance</topic><topic>Ejaculation</topic><topic>Epidemiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Neoplasm Metastasis</topic><topic>Oncology</topic><topic>Orchiectomy</topic><topic>Regular</topic><topic>regular-article</topic><topic>Testicular Neoplasms - drug therapy</topic><topic>Testicular Neoplasms - pathology</topic><topic>Testicular Neoplasms - surgery</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacobsen, K D</creatorcontrib><creatorcontrib>Ous, S</creatorcontrib><creatorcontrib>Wæhre, H</creatorcontrib><creatorcontrib>Trasti, H</creatorcontrib><creatorcontrib>Stenwig, A E</creatorcontrib><creatorcontrib>Lien, H H</creatorcontrib><creatorcontrib>Aass, N</creatorcontrib><creatorcontrib>Fosså, S D</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British Journal of Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacobsen, K D</au><au>Ous, S</au><au>Wæhre, H</au><au>Trasti, H</au><au>Stenwig, A E</au><au>Lien, H H</au><au>Aass, N</au><au>Fosså, S D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ejaculation in testicular cancer patients after post-chemotherapy retroperitoneal lymph node dissection</atitle><jtitle>British Journal of Cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>80</volume><issue>1-2</issue><spage>249</spage><epage>255</epage><pages>249-255</pages><issn>0007-0920</issn><eissn>1476-5381</eissn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>The purpose of this study was to evaluate fertility after different types of post-chemotherapy retroperitoneal lymph node dissection (RPLND). During 1980–1994, 192 patients with metastatic testicular cancer underwent post-chemotherapy RPLND with a gradual shift from modified bilateral template RPLND to nerve-sparing RPLND. Modified bilateral template RPLND was done in 92% of the patients operated during 1980–1984 as compared to 16% during 1989–1994. Pre- and post-treatment fertility was assessed by microscopic sperm analysis, determination of serum FSH and information on ejaculation and paternity. There was no significant difference of the survival rates between the three treatment periods. Antegrade ejaculation was preserved in 11% of the patients after modified bilateral template RPLND as compared to 89% after the nerve-sparing operation technique. The median ejaculatory volume decreased post-operatively, serum FSH increased and sperm density remained unchanged. Fifty-six patients attempted fatherhood after their treatment, and 27 fathered at least one child after an observation-time of 55 months, nine of them by assisted fertilization. Patients with initially advanced testicular cancer but limited residual retroperitoneal masses after induction chemotherapy can safely undergo limited post-chemotherapy RPLND as a part of multimodality treatment. After nerve-sparing RPLND antegrade ejaculation is preserved in 89% of the patients though the ejaculatory volume decreases after RPLND. Post-treatment fatherhood can be achieved in at least 50% of the patients attempting paternity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>10390004</pmid><doi>10.1038/sj.bjc.6690347</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Antineoplastic Agents - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Combined Modality Therapy Drug Resistance Ejaculation Epidemiology Gynecology. Andrology. Obstetrics Humans Lymph Node Excision Male Male genital diseases Medical sciences Middle Aged Molecular Medicine Neoplasm Metastasis Oncology Orchiectomy Regular regular-article Testicular Neoplasms - drug therapy Testicular Neoplasms - pathology Testicular Neoplasms - surgery Treatment Outcome Tumors |
title | Ejaculation in testicular cancer patients after post-chemotherapy retroperitoneal lymph node dissection |
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