Bcl10 is not a target for frequent mutation in human carcinomas

Summary The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have scre...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 1999-07, Vol.80 (10), p.1575-1576
Main Authors: Lambers, A R, Gumbs, C, Ali, S, Marks, J R, Iglehart, J D, Berchuck, A, Futreal, P A
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Adult
B-Cell CLL-Lymphoma 10 Protein
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinogenesis, carcinogens and anticarcinogens
Colorectal Neoplasms - genetics
Drug Resistance
Epidemiology
Female
General aspects
Genital Neoplasms, Female - genetics
Head and Neck Neoplasms - genetics
Humans
Medical sciences
Molecular Medicine
Mutation
Neoplasm Proteins - genetics
Oncology
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Regular
regular-article
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have screened a panel of 174 carcinoma samples in total, comprised of 47 breast, 36 epithelial ovarian, 36 endometrial, 12 cervical, 23 colorectal and 20 head/neck carcinomas, all unselected for grade or stage. This panel reflects, in part, tumours reported to have involvement of the 1p22 region of chromosome 1, the region harbouring the Bcl10 gene. No deleterious mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not a common target for inactivation in adult malignancies and that BCL10 is not the gene targeted for frequent inactivation at 1p22.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6690564