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Influence of tumour size on uptake of111In-DTPA-labelled pegylated liposomes in a human tumour xenograft model
The relationship between tumour size and uptake of 111 In-DTPA-labelled pegylated liposomes has been examined in a human head and neck cancer xenograft model in nude mice. The mean tumour uptake of 111 In-labelled pegylated liposomes at 24 hours was 7.2 ± 6.6% ID/g. Liposome uptake for tumours <...
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| Published in: | British journal of cancer 2000-09, Vol.83 (5), p.684-688 |
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| Main Authors: | , , , , , , |
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| container_end_page | 688 |
| container_issue | 5 |
| container_start_page | 684 |
| container_title | British journal of cancer |
| container_volume | 83 |
| creator | Harrington, K J Rowlinson-Busza, G Syrigos, K N Abra, R M Uster, P S Peters, A M Stewart, J S W |
| description | The relationship between tumour size and uptake of
111
In-DTPA-labelled pegylated liposomes has been examined in a human head and neck cancer xenograft model in nude mice. The mean tumour uptake of
111
In-labelled pegylated liposomes at 24 hours was 7.2 ± 6.6% ID/g. Liposome uptake for tumours < 0.1 g, 0.1–1.0 g and > 1.0 g was 15.1 ± 10.8, 5.9 ± 2.2 and 3.0 ± 1.3% ID/g, respectively. An inverse correlation between tumour weight and liposome uptake was observed by both Spearman’s rank correlation test (r
s
= – 0.573,
P
< 0.001) and Pearson’s correlation coefficient (r
s
= – 0.555,
P
< 0.001). For 18 tumours with macroscopic central necrosis, the ratio of uptake in the tumour rim relative to the necrotic tumour core was 11.2 ± 6.4. Measurement of tumour vascular volume for tumours of various sizes revealed an inverse correlation between tumour weight and tumour vascular volume (Spearman’s rank correlation test, r
s
= – 0.598,
P
< 0.001), consistent with poor or heterogeneous vascularization of larger tumours. These data have important implications for the clinical application of pegylated liposome targeted strategies for solid cancers which are discussed in detail. © 2000 Cancer Research Campaign |
| doi_str_mv | 10.1054/bjoc.2000.1320 |
| format | article |
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111
In-DTPA-labelled pegylated liposomes has been examined in a human head and neck cancer xenograft model in nude mice. The mean tumour uptake of
111
In-labelled pegylated liposomes at 24 hours was 7.2 ± 6.6% ID/g. Liposome uptake for tumours < 0.1 g, 0.1–1.0 g and > 1.0 g was 15.1 ± 10.8, 5.9 ± 2.2 and 3.0 ± 1.3% ID/g, respectively. An inverse correlation between tumour weight and liposome uptake was observed by both Spearman’s rank correlation test (r
s
= – 0.573,
P
< 0.001) and Pearson’s correlation coefficient (r
s
= – 0.555,
P
< 0.001). For 18 tumours with macroscopic central necrosis, the ratio of uptake in the tumour rim relative to the necrotic tumour core was 11.2 ± 6.4. Measurement of tumour vascular volume for tumours of various sizes revealed an inverse correlation between tumour weight and tumour vascular volume (Spearman’s rank correlation test, r
s
= – 0.598,
P
< 0.001), consistent with poor or heterogeneous vascularization of larger tumours. These data have important implications for the clinical application of pegylated liposome targeted strategies for solid cancers which are discussed in detail. © 2000 Cancer Research Campaign</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1054/bjoc.2000.1320</identifier><identifier>PMID: 10944612</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Chemotherapy ; Drug Resistance ; Epidemiology ; Lipids ; Localization ; Medical research ; Molecular Medicine ; Oncology ; Regular ; regular-article ; Response rates ; Tumors</subject><ispartof>British journal of cancer, 2000-09, Vol.83 (5), p.684-688</ispartof><rights>The Author(s) 2000</rights><rights>Copyright Nature Publishing Group Sep 2000</rights><rights>Copyright © 2000 Cancer Research Campaign 2000 Cancer Research Campaign</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2460-c82deece84fc45672edefefe0ff7bdad0c979d046e2786f4d2c77aac31480cb43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363509/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363509/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Harrington, K J</creatorcontrib><creatorcontrib>Rowlinson-Busza, G</creatorcontrib><creatorcontrib>Syrigos, K N</creatorcontrib><creatorcontrib>Abra, R M</creatorcontrib><creatorcontrib>Uster, P S</creatorcontrib><creatorcontrib>Peters, A M</creatorcontrib><creatorcontrib>Stewart, J S W</creatorcontrib><title>Influence of tumour size on uptake of111In-DTPA-labelled pegylated liposomes in a human tumour xenograft model</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><description>The relationship between tumour size and uptake of
111
In-DTPA-labelled pegylated liposomes has been examined in a human head and neck cancer xenograft model in nude mice. The mean tumour uptake of
111
In-labelled pegylated liposomes at 24 hours was 7.2 ± 6.6% ID/g. Liposome uptake for tumours < 0.1 g, 0.1–1.0 g and > 1.0 g was 15.1 ± 10.8, 5.9 ± 2.2 and 3.0 ± 1.3% ID/g, respectively. An inverse correlation between tumour weight and liposome uptake was observed by both Spearman’s rank correlation test (r
s
= – 0.573,
P
< 0.001) and Pearson’s correlation coefficient (r
s
= – 0.555,
P
< 0.001). For 18 tumours with macroscopic central necrosis, the ratio of uptake in the tumour rim relative to the necrotic tumour core was 11.2 ± 6.4. Measurement of tumour vascular volume for tumours of various sizes revealed an inverse correlation between tumour weight and tumour vascular volume (Spearman’s rank correlation test, r
s
= – 0.598,
P
< 0.001), consistent with poor or heterogeneous vascularization of larger tumours. These data have important implications for the clinical application of pegylated liposome targeted strategies for solid cancers which are discussed in detail. © 2000 Cancer Research Campaign</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Chemotherapy</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Lipids</subject><subject>Localization</subject><subject>Medical research</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Regular</subject><subject>regular-article</subject><subject>Response rates</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp1UU1v3CAURFWqZrvtNWeUuzeAWWMukaKkHytFag_pGWF4bLzB4IAdNf31xdq0VQ4Vh8fwZubxNAidUbKhZMsvukM0G0ZIgTUjb9CKbmtW0ZaJE7Qqz6IikpFT9D7nQ4GStOIdOqVEct5QtkJhF5yfIRjA0eFpHuKccO5_FRjwPE76YWlQSnehurn7flV53YH3YPEI-2evp3Lz_RhzHCDjPmCN7-dBhz9WPyHEfdJuwkO04D-gt077DB9f6hr9-Pzp7vprdfvty-766rYyjDekMi2zAAZa7gzfNoKBBVcOcU50VltipJCW8AaYaBvHLTNCaG1qyltiOl6v0eXRd5y7AayBMCXt1Zj6QadnFXWvXndCf6_28Umxuqm3RBaD8xeDFB9nyJM6lHVC-bNiTEpJeSGu0eZIMinmnMD9HUCJWuJRSzxqiUct8RTBxVGQCzHsIf1z_Y_iNyMzlCQ</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Harrington, K J</creator><creator>Rowlinson-Busza, G</creator><creator>Syrigos, K N</creator><creator>Abra, R M</creator><creator>Uster, P S</creator><creator>Peters, A M</creator><creator>Stewart, J S W</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20000901</creationdate><title>Influence of tumour size on uptake of111In-DTPA-labelled pegylated liposomes in a human tumour xenograft model</title><author>Harrington, K J ; 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111
In-DTPA-labelled pegylated liposomes has been examined in a human head and neck cancer xenograft model in nude mice. The mean tumour uptake of
111
In-labelled pegylated liposomes at 24 hours was 7.2 ± 6.6% ID/g. Liposome uptake for tumours < 0.1 g, 0.1–1.0 g and > 1.0 g was 15.1 ± 10.8, 5.9 ± 2.2 and 3.0 ± 1.3% ID/g, respectively. An inverse correlation between tumour weight and liposome uptake was observed by both Spearman’s rank correlation test (r
s
= – 0.573,
P
< 0.001) and Pearson’s correlation coefficient (r
s
= – 0.555,
P
< 0.001). For 18 tumours with macroscopic central necrosis, the ratio of uptake in the tumour rim relative to the necrotic tumour core was 11.2 ± 6.4. Measurement of tumour vascular volume for tumours of various sizes revealed an inverse correlation between tumour weight and tumour vascular volume (Spearman’s rank correlation test, r
s
= – 0.598,
P
< 0.001), consistent with poor or heterogeneous vascularization of larger tumours. These data have important implications for the clinical application of pegylated liposome targeted strategies for solid cancers which are discussed in detail. © 2000 Cancer Research Campaign</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>10944612</pmid><doi>10.1054/bjoc.2000.1320</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2000-09, Vol.83 (5), p.684-688 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2363509 |
| source | PubMed (Medline) |
| subjects | Biomedical and Life Sciences Biomedicine Cancer Research Chemotherapy Drug Resistance Epidemiology Lipids Localization Medical research Molecular Medicine Oncology Regular regular-article Response rates Tumors |
| title | Influence of tumour size on uptake of111In-DTPA-labelled pegylated liposomes in a human tumour xenograft model |
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