Serum midkine levels are increased in patients with various types of carcinomas

The level of expression of midkine (MK), a heparin-binding growth factor, is increased in many types of human carcinomas. An enzyme-linked immunoassay, which utilizes a combination of rabbit and chicken antibodies revealed that serum MK level in the controls ( n = 135) was 0.154 ± 0.076 (mean ± SD)...

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Bibliographic Details
Published in:British journal of cancer 2000-09, Vol.83 (6), p.701-706
Main Authors: Ikematsu, S, Yano, A, Aridome, K, Kikuchi, M, Kumai, H, Nagano, H, Okamoto, K, Oda, M, Sakuma, S, Aikou, T, Muramatsu, H, Kadomatsu, K, Muramatsu, T
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Animals
Antibodies
Antibodies - analysis
Biological and medical sciences
Biomarkers, Tumor - blood
Biomedical and Life Sciences
Biomedicine
Breast Neoplasms - blood
Cancer Research
Carcinoma, Hepatocellular - blood
Carcinoma, Papillary - blood
Carrier Proteins - blood
Chickens
Chromatography
Cytokines
Drug Resistance
Enzyme-Linked Immunosorbent Assay
Epidemiology
Female
Gastrointestinal Neoplasms - blood
Growth factors
Host-tumor relations. Immunology. Biological markers
Humans
Immunoassay
Liver Neoplasms - blood
Lung Neoplasms - blood
Male
Medical prognosis
Medical research
Medical sciences
Middle Aged
Molecular Medicine
Nerve Growth Factors - blood
Neuroblastoma
Oncology
Proteins
Rabbits
Regular
regular-article
Sensitivity and Specificity
Surgery
Thyroid Neoplasms - blood
Tumors
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Summary:The level of expression of midkine (MK), a heparin-binding growth factor, is increased in many types of human carcinomas. An enzyme-linked immunoassay, which utilizes a combination of rabbit and chicken antibodies revealed that serum MK level in the controls ( n = 135) was 0.154 ± 0.076 (mean ± SD) ng ml –1 with an apparent cut-off value as 0.5 ng ml –1 . Serum MK level was significantly elevated in the cancer patients ( n = 150) ( P < 0.001); 87% of the patients showed levels of more than 0.5 ng ml –1 . All ten types of cancer examined showed a similar profile of serum MK level. There was no or weak correlation between C-reactive protein level, a marker of inflammation, and serum MK level. Furthermore, in case of gastric carcinoma and lung carcinoma, patients with stage I carcinoma already showed elevated serum MK levels. The present results indicated that serum MK could serve as a general tumour marker with a good potential for clinical application. © 2000 Cancer Research Campaign
ISSN:0007-0920
1532-1827
DOI:10.1054/bjoc.2000.1339