Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites

We have screened for germline TP53 mutations in Finnish BRCA1 and BRCA2 mutation-negative families. This study represents the largest survey of the entire protein-encoding portion of TP53 , and indicates that mutations are only found at conserved domains in breast cancer families also meeting the cr...

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Bibliographic Details
Published in:British journal of cancer 2001-01, Vol.84 (1), p.116-119
Main Authors: Rapakko, K, Allinen, M, Syrjäkoski, K, Vahteristo, P, Huusko, P, Vähäkangas, K, Eerola, H, Kainu, T, Kallioniemi, O-P, Nevanlinna, H, Winqvist, R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Bone cancer
Breast cancer
Breast Neoplasms - genetics
Cancer Research
Cohort Studies
Conserved Sequence - genetics
Drug Resistance
Epidemiology
Female
Finland - ethnology
Genes
Genes, p53 - genetics
Germ-Line Mutation - genetics
Gynecology. Andrology. Obstetrics
Humans
Kinases
Leukemia
Mammary gland diseases
Medical research
Medical sciences
Molecular Medicine
Mutation
Neoplastic Syndromes, Hereditary - genetics
Oncology
Pedigree
Proteins
Short Communication
Tumor Suppressor Protein p53 - genetics
Tumors
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Description
Summary:We have screened for germline TP53 mutations in Finnish BRCA1 and BRCA2 mutation-negative families. This study represents the largest survey of the entire protein-encoding portion of TP53 , and indicates that mutations are only found at conserved domains in breast cancer families also meeting the criteria for Li-Fraumeni/Li-Fraumeni-like syndrome, explaining only a very small additional fraction of the hereditary breast cancer cases. © 2001 Cancer Research Campaign
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1054/bjoc.2000.1530