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Quantitative measurement of thyroglobulin mRNA in peripheral blood of patients after total thyroidectomy
Previous studies have reported the clinical usefulness of reverse transcription-polymerase chain reaction (RT-PCR) detection of thyroglobulin (TG) mRNA in the peripheral blood of patients with differentiated thyroid carcinoma. To evaluate this usefulness, we measured TG mRNA in the peripheral blood...
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| Published in: | British journal of cancer 2001-07, Vol.85 (1), p.102-106 |
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| container_title | British journal of cancer |
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| creator | Takano, T Miyauchi, A Yoshida, H Hasegawa, Y Kuma, K Amino, N |
| description | Previous studies have reported the clinical usefulness of reverse transcription-polymerase chain reaction (RT-PCR) detection of thyroglobulin (TG) mRNA in the peripheral blood of patients with differentiated thyroid carcinoma. To evaluate this usefulness, we measured TG mRNA in the peripheral blood of patients diagnosed with thyroid carcinoma after total thyroidectomy by real-time quantitative RT-PCR using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as an internal control. Surprisingly, we detected TG mRNA in all samples obtained after total thyroidectomy, including those from 4 medullary carcinomas. Further, there was no statistical difference in expression levels of TG mRNA in the patients with or without metastasis, and no significant correlation was found between serum TG concentrations and the expression levels of TG mRNA. These results give rise to a question regarding the clinical applications of not only RT-PCR detection but also quantitative measurement of TG mRNA in peripheral blood. © 2001 Cancer Research Campaign
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| doi_str_mv | 10.1054/bjoc.2001.1904 |
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http://www.bjcancer.com</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoma</subject><subject>Dehydrogenases</subject><subject>Drug Resistance</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Glyceraldehyde-3-phosphate dehydrogenase</subject><subject>Glyceraldehyde-3-Phosphate Dehydrogenases - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Peripheral blood</subject><subject>Polymerase chain reaction</subject><subject>Regular</subject><subject>regular-article</subject><subject>Reproducibility of Results</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - blood</subject><subject>Statistics</subject><subject>Therapeutic applications</subject><subject>Thyroglobulin</subject><subject>Thyroglobulin - blood</subject><subject>Thyroglobulin - genetics</subject><subject>Thyroid cancer</subject><subject>thyroid carcinoma</subject><subject>Thyroid Neoplasms - blood</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroidectomy</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp9kt2L1DAUxYMo7rj66ptSBMWXzt58NGlehGXxCxZF0eeQNulMhrbpJunC_PemO8OOCvp0Ced3bm5yLkLPMawxVOyi2fl2TQDwGktgD9AKV5SUuCbiIVoBgChBEjhDT2Lc5aOEWjxGZxgzKhiGFdp-m_WYXNLJ3dpisDrOwQ52TIXvirTdB7_pfTP3biyG718ui1wnG9y0tUH3RdN7bxZyyv5sioXukg1F8imrd3ZnbJv8sH-KHnW6j_bZsZ6jnx_e_7j6VF5__fj56vK6bDmwVJpKg64NcGsYrWpORGurjhAssw4VSGO6pmqoZMZwTKSQDTWNNNgYBh1n9By9O_Sd5mawps1T5UnVFNygw1557dSfyui2auNvFaGcSixzgzfHBsHfzDYmNbjY2r7Xo_VzVAJkLXi13PT2vyCmhNbARM0z-uovdOfnMOZ_UIRIKTljJEPrA9QGH2Ow3f3QGNQStlrCVkvYagk7G17-_tQTfkw3A6-PgI6t7rugx9bFE8dA8Lwqmbs4cDFL48aG03j_vPrFwTHqlBfmviXn8k7_BdhTzeE</recordid><startdate>20010706</startdate><enddate>20010706</enddate><creator>Takano, T</creator><creator>Miyauchi, A</creator><creator>Yoshida, H</creator><creator>Hasegawa, Y</creator><creator>Kuma, K</creator><creator>Amino, N</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010706</creationdate><title>Quantitative measurement of thyroglobulin mRNA in peripheral blood of patients after total thyroidectomy</title><author>Takano, T ; Miyauchi, A ; Yoshida, H ; Hasegawa, Y ; Kuma, K ; Amino, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-d5a0a8d06ed4358627ce5f2219c600509ddfb5b394dd612979b3db9d1dd40f643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoma</topic><topic>Dehydrogenases</topic><topic>Drug Resistance</topic><topic>Endocrinopathies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Glyceraldehyde-3-phosphate dehydrogenase</topic><topic>Glyceraldehyde-3-Phosphate Dehydrogenases - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Peripheral blood</topic><topic>Polymerase chain reaction</topic><topic>Regular</topic><topic>regular-article</topic><topic>Reproducibility of Results</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - blood</topic><topic>Statistics</topic><topic>Therapeutic applications</topic><topic>Thyroglobulin</topic><topic>Thyroglobulin - blood</topic><topic>Thyroglobulin - genetics</topic><topic>Thyroid cancer</topic><topic>thyroid carcinoma</topic><topic>Thyroid Neoplasms - blood</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroid. 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To evaluate this usefulness, we measured TG mRNA in the peripheral blood of patients diagnosed with thyroid carcinoma after total thyroidectomy by real-time quantitative RT-PCR using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA as an internal control. Surprisingly, we detected TG mRNA in all samples obtained after total thyroidectomy, including those from 4 medullary carcinomas. Further, there was no statistical difference in expression levels of TG mRNA in the patients with or without metastasis, and no significant correlation was found between serum TG concentrations and the expression levels of TG mRNA. These results give rise to a question regarding the clinical applications of not only RT-PCR detection but also quantitative measurement of TG mRNA in peripheral blood. © 2001 Cancer Research Campaign
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| subjects | Adolescent Adult Aged Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma Dehydrogenases Drug Resistance Endocrinopathies Epidemiology Female Glyceraldehyde-3-phosphate dehydrogenase Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Humans Male Malignant tumors Medical research Medical sciences Metastases Metastasis Middle Aged Molecular Medicine Oncology Peripheral blood Polymerase chain reaction Regular regular-article Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - blood Statistics Therapeutic applications Thyroglobulin Thyroglobulin - blood Thyroglobulin - genetics Thyroid cancer thyroid carcinoma Thyroid Neoplasms - blood Thyroid Neoplasms - genetics Thyroid Neoplasms - surgery Thyroid. Thyroid axis (diseases) Thyroidectomy |
| title | Quantitative measurement of thyroglobulin mRNA in peripheral blood of patients after total thyroidectomy |
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