Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis

Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with exp...

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Bibliographic Details
Published in:British journal of cancer 2002-09, Vol.87 (7), p.756-762
Main Authors: Løvig, T, Andersen, S N, Thorstensen, L, Diep, C B, Meling, G I, Lothe, R A, Rognum, T O
Format: Article
Language:English
Subjects:
Age Factors
Aged
Antigens
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Chromosomes
Colonic Neoplasms - diagnosis
Colonic Neoplasms - genetics
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Colorectal cancer
Cytotoxicity
Disease Susceptibility
Drug Resistance
Epidemiology
Female
Gene Expression Regulation, Neoplastic
HLA-DR Antigens - immunology
HLA-DR Antigens - metabolism
Humans
Immunohistochemistry
Lymphocytes
Male
Medical prognosis
Medical research
Microsatellite Repeats - genetics
Middle Aged
Molecular and Cellular Pathology
Molecular Medicine
Neoplasm Staging
Oncology
Patients
Prognosis
Proportional Hazards Models
Sex Characteristics
Survival Analysis
Tumors
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Summary:Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antigens on their tumour cells. In this study, the expression of HLA-DR antigen was investigated by immunohistochemistry in 357 large bowel carcinomas stratified by microsatellite instability status. Sixteen per cent of the tumours showed strong HLA-DR expression and 35% had weak DR expression. We confirmed that patients with strong positive HLA-DR staining had improved survival ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6600507