Peptide‐plane flipping in proteins

A peptide‐plane flip is a large‐scale rotation of the peptide plane that takes the ϕ,ψ angles at residues i and i + 1 to different structural regions in the Ramachandran plot with a comparatively small effect on the relative orientation of their side chains. This phenomenon, which is expected to pla...

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Bibliographic Details
Published in:Protein science 2001-11, Vol.10 (11), p.2219-2227
Main Author: Hayward, Steven
Format: Article
Language:English
Subjects:
Backbone dihedrals
Hydrogen Bonding
left‐handed α‐helix
Mathematics
Peptides - chemistry
Protein Conformation
protein folding
Proteins - chemistry
Ramachandran plot
structural interconversion
Thermodynamics
X-Ray Diffraction
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Summary:A peptide‐plane flip is a large‐scale rotation of the peptide plane that takes the ϕ,ψ angles at residues i and i + 1 to different structural regions in the Ramachandran plot with a comparatively small effect on the relative orientation of their side chains. This phenomenon, which is expected to play an important role during the early stages of protein folding, has been investigated using 76 proteins for which two high‐resolution X‐ray conformations are available. Peptide‐plane flips are identified by looking for those cases where changes in |ψi| + |ϕi + 1| are large (>200°), but changes in |ψi + ϕi + 1| are comparatively small (
ISSN:0961-8368
1469-896X
DOI:10.1110/ps.23101