Heparan sulfate proteoglycans and cancer

Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached. The existence of various classes of core pr...

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Bibliographic Details
Published in:British journal of cancer 2001-10, Vol.85 (8), p.1094-1098
Main Authors: Blackhall, F H, Merry, C L R, Davies, E J, Jayson, G C
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinogenesis, carcinogens and anticarcinogens
Cell Division
Cell growth
Chemokines
Drug Resistance
Epidemiology
Extracellular matrix
General aspects
Glucuronidase - physiology
Glycosylation
Glypicans
Growth factors
Heparan sulfate
Heparan Sulfate Proteoglycans - physiology
Heparitin Sulfate - biosynthesis
Humans
Ligands
Medical prognosis
Medical research
Medical sciences
Molecular Medicine
Multiple myeloma
Neoplasm Invasiveness
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - therapy
Neovascularization, Pathologic - etiology
Oncology
Pancreatic cancer
Proteins
Review
Tumors
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Description
Summary:Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached. The existence of various classes of core protein, in addition to highly polymorphic HS chains, creates a superfamily of macromolecules with considerable diversity of structure and function. HSPGs interact with many proteins including growth factors, chemokines and structural proteins of the extracellular matrix to influence cell growth, differentiation, and the cellular response to the environment. The recent identification of two inherited syndromes that are associated with an increased cancer risk, and caused by mutations in HSPG-related genes, has intensified interest in these molecules. This review describes our current understanding of HSPGs in cancer and highlights new possibilities for therapeutic control. © 2001 Cancer Research Campaign http://www.bjcancer.com
ISSN:0007-0920
1532-1827
DOI:10.1054/bjoc.2001.2054