Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

• Published in: The Journal of physiology 2008-01, Vol.586 (1), p.151-160
• Main Authors: Burgomaster, Kirsten A., Howarth, Krista R., Phillips, Stuart M., Rakobowchuk, Mark, MacDonald, Maureen J., McGee, Sean L., Gibala, Martin J.
• Format: Article
• Language: English
• Subjects: Adaptation, Biological - physiology; Adult; Biopsy; Carbohydrate Metabolism - physiology; Energy Metabolism - physiology; Exercise - physiology; Exercise Test; Female; Heat-Shock Proteins - metabolism; Humans; Lipid Metabolism - physiology; Male; Muscle, Skeletal - enzymology; Muscle, Skeletal - pathology; Oxygen Consumption - physiology; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Endurance - physiology; Special Section Related Papers; Time Factors; Transcription Factors - metabolism
• ISSN: 0022-3751; 1469-7793
• DOI: 10.1113/jphysiol.2007.142109

Low-volume ‘sprint’ interval training (SIT) stimulates rapid improvements in muscle oxidative capacity that are comparable to levels reached following traditional endurance training (ET) but no study has examined metabolic adaptations during exercise after these different training strategies. We hypothesized that SIT and ET would induce similar adaptations in markers of skeletal muscle carbohydrate (CHO) and lipid metabolism and metabolic control during exercise despite large differences in training volume and time commitment. Active but untrained subjects (23 ± 1 years) performed a constant-load cycling challenge (1 h at 65% of peak oxygen uptake before and after 6 weeks of either SIT or ET ( n = 5 men and 5 women per group). SIT consisted of four to six repeats of a 30 s ‘all out’ Wingate Test (mean power output ∼500 W) with 4.5 min recovery between repeats, 3 days per week. ET consisted of 40–60 min of continuous cycling at a workload that elicited ∼65% (mean power output ∼150 W) per day, 5 days per week. Weekly time commitment (∼1.5 versus ∼4.5 h) and total training volume (∼225 versus ∼2250 kJ week −1 ) were substantially lower in SIT versus ET. Despite these differences, both protocols induced similar increases ( P < 0.05) in mitochondrial markers for skeletal muscle CHO (pyruvate dehydrogenase E1α protein content) and lipid oxidation (3-hydroxyacyl CoA dehydrogenase maximal activity) and protein content of peroxisome proliferator-activated receptor-γ coactivator-1α. Glycogen and phosphocreatine utilization during exercise were reduced after training, and calculated rates of whole-body CHO and lipid oxidation were decreased and increased, respectively, with no differences between groups (all main effects, P < 0.05). Given the markedly lower training volume in the SIT group, these data suggest that high-intensity interval training is a time-efficient strategy to increase skeletal muscle oxidative capacity and induce specific metabolic adaptations during exercise that are comparable to traditional ET.