Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome

Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of ment...

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Bibliographic Details
Published in:The Journal of physiology 2008-03, Vol.586 (6), p.1503-1508
Main Authors: Dölen, Gül, Bear, Mark F
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Brain - pathology
Fragile X Syndrome - metabolism
Fragile X Syndrome - pathology
Mice
Mice, Knockout
Neurons - metabolism
Neurons - pathology
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate - metabolism
Symposium Section Reports: New Directions in Synaptic and Network Plasticity
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Summary:Metabotropic glutamate receptors (mGluRs) have been implicated in a diverse variety of neuronal functions. Studies reviewed here indicate that exaggerated signalling through mGluR5 can account for multiple cognitive and syndromic features of fragile X syndrome, the most common inherited form of mental retardation and autism. Since a reduction of mGluR5 signalling can reverse fragile X phenotypes, these studies provide a compelling rationale for the use of mGluR5 antagonists for the treatment of fragile X and related disorders.
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.2008.150722