Bone metastases from breast carcinoma: histopathological - radiological correlations and prognostic features

The aim of this study was to identify factors that may be associated with the development of bone metastases in patients with metastatic breast carcinoma and to see if any of these factors had a bearing on subsequent survival. In total, 492 patients presented to the Nottingham City Hospital with met...

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Bibliographic Details
Published in:British journal of cancer 2003-08, Vol.89 (4), p.660-665
Main Authors: James, J J, Evans, A J, Pinder, S E, Gutteridge, E, Cheung, K L, Chan, S, Robertson, J F R
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Antigens, Neoplasm - analysis
Biological and medical sciences
Biomarkers, Tumor - analysis
Biomedical and Life Sciences
Biomedicine
Bone Neoplasms - chemistry
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - secondary
Breast Neoplasms - chemistry
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Cancer Research
Carcinoembryonic Antigen - analysis
Drug Resistance
Epidemiology
Female
Gynecology. Andrology. Obstetrics
Humans
Magnetic Resonance Imaging
Mammary gland diseases
Medical sciences
Middle Aged
Molecular and Cellular Pathology
Molecular Medicine
Mucin-1 - analysis
Oncology
Prognosis
Prospective Studies
Radionuclide Imaging
Receptors, Estrogen - analysis
Survival Rate
Time Factors
Tomography, X-Ray Computed
Tumors
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Summary:The aim of this study was to identify factors that may be associated with the development of bone metastases in patients with metastatic breast carcinoma and to see if any of these factors had a bearing on subsequent survival. In total, 492 patients presented to the Nottingham City Hospital with metastatic breast carcinoma between July 1997 and December 2001. Of these, 267 patients had bone metastases at presentation with metastatic disease, 91 patients in this group had bone as their only site of metastatic disease. Sites of first presentation of metastatic disease were prospectively recorded, as were histological features of the primary tumour (tumour type, histological grade, lymph node stage, tumour size and oestrogen receptor (ER) status). The radiological features of the bone metastases, the metastasis-free interval and serological tumour marker levels at presentation with metastases were all recorded. There was a significant association between the development of bone metastases and lower grade tumours ( P =0.019), ER-positive tumours ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6601198