Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma

A significant frequency of mutations (six missense and one silent) was found, for the first time, at the coding region of the bak gene (exons 3, 4 and 6) in 42 carcinomas of the uterine cervix, while no mutations were detected in 32 non-neoplastic cervix tissues. Bak mutations were observed more fre...

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Bibliographic Details
Published in:British journal of cancer 2003-05, Vol.88 (10), p.1584-1586
Main Authors: Wani, K M Y, Huilgol, N G, Hongyo, T, Ryo, H, Shah, K, Chatterjee, N, Nair, C K K, Nomura, T
Format: Article
Language:English
Subjects:
Adult
Apoptosis
bcl-2 Homologous Antagonist-Killer Protein
Biological and medical sciences
Biology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma - genetics
Carcinoma - radiotherapy
Cervical cancer
Cervix
DNA Mutational Analysis
Drug dosages
Drug Resistance
Epidemiology
Female
Genes
Genes, Tumor Suppressor
Genetics and Genomics
Genital system. Mammary gland
Hospitals
Human papillomavirus
Humans
Medical research
Medical sciences
Membrane Proteins - genetics
Middle Aged
Molecular Medicine
Mutation
Mutation, Missense
Oncology
Proto-Oncogene Proteins c-bcl-2
Radiation therapy
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Sample Size
Uterine Cervical Neoplasms - genetics
Uterine Cervical Neoplasms - radiotherapy
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Summary:A significant frequency of mutations (six missense and one silent) was found, for the first time, at the coding region of the bak gene (exons 3, 4 and 6) in 42 carcinomas of the uterine cervix, while no mutations were detected in 32 non-neoplastic cervix tissues. Bak mutations were observed more frequently in the advanced stage and mutated cancer tissues were more resistant to radiotherapy, although trends were not statistically significant because of small sample size.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6600944