Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings

Abstract Background The purpose of this study was to examine substance use and dependence among cocaine dependent subjects and their siblings compared to individuals recruited from the same neighborhood and their siblings in order to better understand family and neighborhood contributions to the dev...

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Bibliographic Details
Published in:Drug and alcohol dependence 2008-05, Vol.95 (1), p.14-22
Main Authors: Bierut, Laura Jean, Strickland, Jaime R, Thompson, Jeremy R, Afful, Stephanie E, Cottler, Linda B
Format: Article
Language:English
Subjects:
Addictive behaviors
Adult
Adult and adolescent clinical studies
Alcohol dependence
Alcoholism - epidemiology
Alcoholism - genetics
Alcoholism - rehabilitation
Biological and medical sciences
Cluster Analysis
Cocaine
Cocaine dependence
Cocaine-Related Disorders - epidemiology
Cocaine-Related Disorders - genetics
Cocaine-Related Disorders - rehabilitation
Comorbidity
Cross-Sectional Studies
Drug addiction
Family study
Female
Genetic Predisposition to Disease - genetics
Health Surveys
Humans
Male
Marijuana Abuse - epidemiology
Marijuana Abuse - genetics
Marijuana Abuse - rehabilitation
Matched-Pair Analysis
Medical sciences
Middle Aged
Missouri
Neighborhood
Neuropharmacology
Opioid-Related Disorders - epidemiology
Opioid-Related Disorders - genetics
Opioid-Related Disorders - rehabilitation
Pharmacology. Drug treatments
Polydrug use
Psychiatry
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Residence Characteristics
Risk Factors
Siblings
Smoking - epidemiology
Social Environment
Street Drugs
Substance Abuse Detection - statistics & numerical data
Substance Abuse, Intravenous - epidemiology
Substance Abuse, Intravenous - genetics
Substance Abuse, Intravenous - rehabilitation
Substance-Related Disorders - epidemiology
Substance-Related Disorders - genetics
Substance-Related Disorders - rehabilitation
Toxicology
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Summary:Abstract Background The purpose of this study was to examine substance use and dependence among cocaine dependent subjects and their siblings compared to individuals recruited from the same neighborhood and their siblings in order to better understand family and neighborhood contributions to the development of dependence. Methods Cocaine dependent subjects were recruited through treatment centers. Community-based subjects were matched to cocaine dependent index cases on age, ethnicity, gender, and zip code. One full sibling for each case and community-based subject participated. Results Cocaine dependent subjects were significantly more likely than community-based subjects to use all substances studied and were 2–10 times more likely to be dependent on alcohol and other illicit drugs. Dependence only on cocaine was uncommon (
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2007.11.023