Neuroglobin: an endogenous neuroprotectant

Cerebral hypoxia and ischemia trigger endogenous protective mechanisms that can prevent or limit brain damage. Understanding these mechanisms may lead to new therapeutic strategies for stroke and related disorders. Neuroglobin (Ngb), a recently discovered protein that is distantly related to hemoglo...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in pharmacology 2008-02, Vol.8 (1), p.20-24
Main Authors: Greenberg, David A, Jin, Kunlin, Khan, Adil A
Format: Article
Language:English
Subjects:
Animals
Globins - genetics
Globins - physiology
Humans
Hypoxia-Ischemia, Brain - prevention & control
Internal Medicine
Medical Education
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - physiology
Neurodegenerative Diseases - prevention & control
Neuroprotective Agents
Nitric Oxide - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cerebral hypoxia and ischemia trigger endogenous protective mechanisms that can prevent or limit brain damage. Understanding these mechanisms may lead to new therapeutic strategies for stroke and related disorders. Neuroglobin (Ngb), a recently discovered protein that is distantly related to hemoglobin and myoglobin, is expressed predominantly in brain neurons, and appears to modulate hypoxic–ischemic brain injury. Evidence includes the observations that neuronal hypoxia and cerebral ischemia induce Ngb expression, that enhancing Ngb expression reduces — and knocking down Ngb expression increases — hypoxic neuronal injury in vitro and ischemic cerebral injury in vivo , and that Ngb-overexpressing transgenic mice are resistant to cerebral infarction. However, the mechanisms that underlie hypoxic induction of Ngb and neuroprotection by Ngb are still unclear.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2007.09.003