Prospective study of high-dose chemotherapy and autologous peripheral stem cell transplantation in adult patients with advanced desmoplastic small round-cell tumour

A total of 10 desmoplastic small round-cell tumour patients were treated by high-dose chemotherapy with stem cell support. After high-dose chemotherapy, no complete response conversion was obtained and EWS-WT1 fusion transcript detection was positive in the peripheral blood during follow-up in all p...

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Bibliographic Details
Published in:British journal of cancer 2003-10, Vol.89 (7), p.1159-1161
Main Authors: Bertuzzi, A, Castagna, L, Quagliuolo, V, Ginanni, V, Compasso, S, Magagnoli, M, Balzarotti, M, Nozza, A, Siracusano, L, Timofeeva, I, Sarina, B, Parra, H Soto, Santoro, A
Format: Article
Language:English
Subjects:
Abdominal Neoplasms - genetics
Abdominal Neoplasms - therapy
Adolescent
Adult
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cancer Research
Cancer therapies
Carcinoma, Small Cell - genetics
Carcinoma, Small Cell - therapy
Chemotherapy
Clinical
Combined Modality Therapy
Combined treatments (chemotherapy of immunotherapy associated with an other treatment)
DNA Primers - chemistry
Drug Resistance
Epidemiology
Humans
Male
Medical research
Medical sciences
Middle Aged
Molecular Medicine
Oncogene Proteins, Fusion - genetics
Oncogene Proteins, Fusion - metabolism
Oncology
Peripheral Blood Stem Cell Transplantation
Pharmacology. Drug treatments
Prognosis
Prospective Studies
Radiation therapy
Remission (Medicine)
Reverse Transcriptase Polymerase Chain Reaction
Stem cell transplantation
Surgery
Survival Rate
Transplantation, Autologous
Treatment Outcome
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Summary:A total of 10 desmoplastic small round-cell tumour patients were treated by high-dose chemotherapy with stem cell support. After high-dose chemotherapy, no complete response conversion was obtained and EWS-WT1 fusion transcript detection was positive in the peripheral blood during follow-up in all patients. High-dose chemotherapy did not seem to change the results in desmoplastic small round-cell tumour.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6601304