Height, body mass index, and prostate cancer: a follow-up of 950 000 Norwegian men

The present study explored body mass index (BMI), height, and risk of prostate cancer in a large Norwegian cohort of 950 000 men aged 20–74 years, whose height and weight were measured in a standardised way in the period 1963–1999. These were followed for an average of 21 years. The Cox proportional...

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Bibliographic Details
Published in:British journal of cancer 2003-10, Vol.89 (7), p.1237-1242
Main Authors: Engeland, A, Tretli, S, Bjørge, T
Format: Article
Language:English
Subjects:
Age
Biomedical and Life Sciences
Biomedicine
Body mass index
Cancer Research
Cohort analysis
Drug Resistance
Epidemiology
Medical research
Molecular Medicine
Obesity
Oncology
Overweight
Prostate cancer
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Summary:The present study explored body mass index (BMI), height, and risk of prostate cancer in a large Norwegian cohort of 950 000 men aged 20–74 years, whose height and weight were measured in a standardised way in the period 1963–1999. These were followed for an average of 21 years. The Cox proportional hazard models were used in the analyses. During follow-up, 33 300 histologically verified cases of prostate cancer were registered. The risk of prostate cancer increased by both BMI and height. The magnitude of the increase by BMI was modest, the relative risk (RR) of obese men (BMI⩾30) compared with normal weighted was 1.09 (95% CI: 1.04–1.15). However, the RR at age 50–59 years was 1.58 (95% CI: 1.29–1.94) in men being obese at about age 45 years compared with normal weighted men. The tallest men had an RR of 1.72 (95% CI: 1.46–2.04) compared with the shortest men. The overall effect of BMI on the incidence of prostate cancer was modest. The larger effect found in men aged 50–59 years might partly explain the previous inconsistent findings.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6601206