Granulomatous enteropathy in common variable immunodeficiency: a cause of chronic diarrhoea

Gastrointestinal disease is a well recognized feature in patients with common variable immunodeficiency, and is often due to infection with a variety of organisms. Symptoms usually improve with appropriate antibiotic therapy and replacement gammaglobulin. We describe three middle-aged female patient...

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Bibliographic Details
Published in:Postgraduate medical journal 1991-05, Vol.67 (787), p.446-449
Main Authors: Mike, N., Hansel, T. T., Newman, J., Asquith, P.
Format: Article
Language:English
Subjects:
Adult
Agammaglobulinemia - complications
Biological and medical sciences
Chronic Disease
Diarrhea - etiology
Digestive System - pathology
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Diseases - complications
Gastrointestinal Diseases - etiology
Gastrointestinal Diseases - pathology
Granuloma - complications
Granuloma - etiology
Granuloma - pathology
Humans
Medical sciences
Middle Aged
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Summary:Gastrointestinal disease is a well recognized feature in patients with common variable immunodeficiency, and is often due to infection with a variety of organisms. Symptoms usually improve with appropriate antibiotic therapy and replacement gammaglobulin. We describe three middle-aged female patients with common variable immunodeficiency who had protracted diarrhoea and weight loss. Despite extensive investigation no infectious cause was found. All patients had granulomas distributed throughout the gastrointestinal tract, but no features of inflammatory bowel disease. There was a poor response to gammaglobulin replacement therapy, antibiotics or symptomatic treatment. We suggest that granulomatous enteropathy is another gastrointestinal manifestation of common variable immunodeficiency.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.67.787.446