A pharmacokinetic interaction between cimetidine or ranitidine and lornoxicam

Cimetidine 400 mg twice daily significantly increased serum concentrations and reduced apparent oral clearance of lornoxicam 8 mg twice daily in 12 healthy volunteers. Ranitidine 150 mg twice daily produced no significant changes in lornoxicam pharmacokinetics.

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Bibliographic Details
Published in:Postgraduate medical journal 1993-11, Vol.69 (817), p.865-866
Main Authors: Ravic, M., Salas-Herrera, I., Johnston, A., Turner, P., Foley, K., Rosenow, D. E.
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Biological and medical sciences
Cimetidine - pharmacokinetics
Drug Interactions
Female
General pharmacology
Humans
Male
Medical sciences
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Piroxicam - analogs & derivatives
Piroxicam - pharmacokinetics
Ranitidine - pharmacokinetics
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Description
Summary:Cimetidine 400 mg twice daily significantly increased serum concentrations and reduced apparent oral clearance of lornoxicam 8 mg twice daily in 12 healthy volunteers. Ranitidine 150 mg twice daily produced no significant changes in lornoxicam pharmacokinetics.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.69.817.865