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Lymphoreticular diseases in Nigerians
Background: The lymphoreticular system plays a major role in both the innate and adaptive immune responses. This study reviews retrospectively cases of lymphoreticular diseases seen at a tertiary institution in Nigeria. Materials and Methods: This is a retrospective study in which biopsies from the...
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Published in: | African health sciences 2008-03, Vol.8 (1), p.20-24 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Background: The lymphoreticular system plays a major role in both the
innate and adaptive immune responses. This study reviews
retrospectively cases of lymphoreticular diseases seen at a tertiary
institution in Nigeria. Materials and Methods: This is a retrospective
study in which biopsies from the bone marrow, spleen, lymph nodes and
extranodal lymphoid tissues reported within a period of 16 years were
reviewed with respect to age, sex and pathological diagnosis.
Statistical analysis was performed for differences in proportion using
Chi square by SPSS version 12. Results: Nine hundred and forty four
cases comprising 559 biopsies from lymph nodes and extranodal lymphoid
tissues, 272 bone marrow biopsies and 113 spleen biopsies were studied.
Non Hodgkin's lymphoma (NHL) and tuberculosis were the most common
lesions in lymph nodes and extranodal lymphoid tissues. The axillary
and cervical nodes accounted for most cases of metastasis. Breast
cancer accounted for the majority of metastasis to lymph nodes. The
most common pathological changes in bone marrow were NHL and reactive
hyperplasia. Patients with chronic lymphocytic leukaemia (CLL) had the
highest mean age, which was significantly higher than in those with NHL
(p=.001, 95% confidence interval -27.91 to -7.76). The most common
finding in the spleen was splenic rupture and haemoperitoneum from road
traffic accident. Conclusion: NHL and tuberculosis should be high on
the list of differential diagnosis of lymphadenopathy in Nigerians.
Whereas trauma from RTA was the major reason for splenectomy in
Nigerians, in the elderly splenic biopsy would likely show CLL. |
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ISSN: | 1680-6905 1729-0503 |