Discovering mechanisms of signaling-mediated cysteine oxidation

Accumulating evidence reveals hydrogen peroxide as a key player both as a damaging agent and, from emerging evidence over the past decade, as a second messenger in intracellular signaling. This rather mild oxidant acts upon downstream targets within signaling cascades to modulate the activity of a h...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in chemical biology 2008-02, Vol.12 (1), p.18-24
Main Authors: Poole, Leslie B, Nelson, Kimberly J
Format: Article
Language:English
Subjects:
Cysteine - chemistry
Cysteine - metabolism
Humans
Hydrogen Peroxide - metabolism
Oxidation-Reduction
Peroxiredoxins - chemistry
Peroxiredoxins - metabolism
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Accumulating evidence reveals hydrogen peroxide as a key player both as a damaging agent and, from emerging evidence over the past decade, as a second messenger in intracellular signaling. This rather mild oxidant acts upon downstream targets within signaling cascades to modulate the activity of a host of enzymes (e.g. phosphatases and kinases) and transcriptional regulators through chemoselective oxidation of cysteine residues. With the recent development of specific detection reagents for hydrogen peroxide and new chemical tools to detect the generation of the initial oxidation product, sulfenic acid, on reactive cysteines within target proteins, the scene is set to gain a better understanding of the mechanisms through which hydrogen peroxide acts as a second messenger in cell signaling.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2008.01.021