Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines

In addition to hypoxia, acidic extracellular pH (pH e ) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperther...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2004-05, Vol.90 (9), p.1842-1849
Main Authors: Kalliomäki, T, Hill, R P
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine - pharmacology
Acidification
Acidosis
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Cell Hypoxia - drug effects
Drug Resistance
Epidemiology
Experimental Therapeutics
Female
Fibrosarcoma
Fibrosarcoma - chemistry
Fibrosarcoma - drug therapy
Glucose
Glucose - pharmacology
Hydrogen-Ion Concentration
Hyperthermia
Hypoxia
Male
Medical research
Medical sciences
Melanoma
Melanoma, Experimental - chemistry
Melanoma, Experimental - drug therapy
Metastasis
Mice
Molecular Medicine
Neoplasm Metastasis - pathology
Oncology
Tumor Cells, Cultured
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In addition to hypoxia, acidic extracellular pH (pH e ) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previous data have shown that exposure of murine tumour cells to acid conditions in culture can enhance their metastatic potential when injected subsequently into mice, raising the concern that deliberate tumour acidification might increase the probability of metastasis. In this study, we examined the effects of in vivo tumour acidification and hypoxia on the spontaneous metastatic potential of the murine KHT-C fibrosarcoma and B16F1 melanoma cell lines. A tumour-specific increase in extracellular acidity, demonstrated by measurements with pH electrodes, was achieved by daily intraperitoneal injections of meta-iodo-benzylguanidine (MIBG) and/or glucose. This method of tumour acidification during tumour growth did not significantly enhance the spontaneous metastatic potential of the two murine cell lines.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6601766