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Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines
In addition to hypoxia, acidic extracellular pH (pH e ) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperther...
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| Published in: | British journal of cancer 2004-05, Vol.90 (9), p.1842-1849 |
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| creator | Kalliomäki, T Hill, R P |
| description | In addition to hypoxia, acidic extracellular pH (pH
e
) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previous data have shown that exposure of murine tumour cells to acid conditions in culture can enhance their metastatic potential when injected subsequently into mice, raising the concern that deliberate tumour acidification might increase the probability of metastasis. In this study, we examined the effects of
in vivo
tumour acidification and hypoxia on the spontaneous metastatic potential of the murine KHT-C fibrosarcoma and B16F1 melanoma cell lines. A tumour-specific increase in extracellular acidity, demonstrated by measurements with pH electrodes, was achieved by daily intraperitoneal injections of meta-iodo-benzylguanidine (MIBG) and/or glucose. This method of tumour acidification during tumour growth did not significantly enhance the spontaneous metastatic potential of the two murine cell lines. |
| doi_str_mv | 10.1038/sj.bjc.6601766 |
| format | article |
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) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previous data have shown that exposure of murine tumour cells to acid conditions in culture can enhance their metastatic potential when injected subsequently into mice, raising the concern that deliberate tumour acidification might increase the probability of metastasis. In this study, we examined the effects of
in vivo
tumour acidification and hypoxia on the spontaneous metastatic potential of the murine KHT-C fibrosarcoma and B16F1 melanoma cell lines. A tumour-specific increase in extracellular acidity, demonstrated by measurements with pH electrodes, was achieved by daily intraperitoneal injections of meta-iodo-benzylguanidine (MIBG) and/or glucose. This method of tumour acidification during tumour growth did not significantly enhance the spontaneous metastatic potential of the two murine cell lines.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/sj.bjc.6601766</identifier><identifier>PMID: 15150590</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>3-Iodobenzylguanidine - pharmacology ; Acidification ; Acidosis ; Animals ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cancer therapies ; Cell Hypoxia - drug effects ; Drug Resistance ; Epidemiology ; Experimental Therapeutics ; Female ; Fibrosarcoma ; Fibrosarcoma - chemistry ; Fibrosarcoma - drug therapy ; Glucose ; Glucose - pharmacology ; Hydrogen-Ion Concentration ; Hyperthermia ; Hypoxia ; Male ; Medical research ; Medical sciences ; Melanoma ; Melanoma, Experimental - chemistry ; Melanoma, Experimental - drug therapy ; Metastasis ; Mice ; Molecular Medicine ; Neoplasm Metastasis - pathology ; Oncology ; Tumor Cells, Cultured ; Tumors</subject><ispartof>British journal of cancer, 2004-05, Vol.90 (9), p.1842-1849</ispartof><rights>The Author(s) 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 4, 2004</rights><rights>Copyright © 2004 Cancer Research UK 2004 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3986-febca580bc2facc2eb6d70b3408ffe4eaffcd2c77de09dc2e18058d6ea83f3c13</citedby><cites>FETCH-LOGICAL-c3986-febca580bc2facc2eb6d70b3408ffe4eaffcd2c77de09dc2e18058d6ea83f3c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409743/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409743/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15760812$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15150590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalliomäki, T</creatorcontrib><creatorcontrib>Hill, R P</creatorcontrib><title>Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>In addition to hypoxia, acidic extracellular pH (pH
e
) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previous data have shown that exposure of murine tumour cells to acid conditions in culture can enhance their metastatic potential when injected subsequently into mice, raising the concern that deliberate tumour acidification might increase the probability of metastasis. In this study, we examined the effects of
in vivo
tumour acidification and hypoxia on the spontaneous metastatic potential of the murine KHT-C fibrosarcoma and B16F1 melanoma cell lines. A tumour-specific increase in extracellular acidity, demonstrated by measurements with pH electrodes, was achieved by daily intraperitoneal injections of meta-iodo-benzylguanidine (MIBG) and/or glucose. This method of tumour acidification during tumour growth did not significantly enhance the spontaneous metastatic potential of the two murine cell lines.</description><subject>3-Iodobenzylguanidine - pharmacology</subject><subject>Acidification</subject><subject>Acidosis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cancer therapies</subject><subject>Cell Hypoxia - drug effects</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Experimental Therapeutics</subject><subject>Female</subject><subject>Fibrosarcoma</subject><subject>Fibrosarcoma - chemistry</subject><subject>Fibrosarcoma - drug therapy</subject><subject>Glucose</subject><subject>Glucose - pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hyperthermia</subject><subject>Hypoxia</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Melanoma</subject><subject>Melanoma, Experimental - chemistry</subject><subject>Melanoma, Experimental - drug therapy</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Molecular Medicine</subject><subject>Neoplasm Metastasis - pathology</subject><subject>Oncology</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp1kc1v1DAQxS0EokvhyhFZSHBB2Y7txHYulaAqpVIRFzhbjmPvOkrixXao-O9x2YgWJE7-mN88v_FD6CWBLQEmz9Kw7Qaz5RyI4PwR2pCG0YpIKh6jDQCICloKJ-hZSkM5tiDFU3RCGtJA08IGxUvnrMkJB4fzMoUlYm187503Ovsw41uf93g3LiYk--7z9YcrXC7z3uJ0CHPWsw1LwpPNOuXSYPAhZDtnr8ffircBT0v0s8XGjiMeyy49R0-cHpN9sa6n6NvHy68Xn6qbL1fXF-9vKsNayStnO6MbCZ2hThtDbcd7AR2rQRbLtdXOmZ4aIXoLbV_qREIje261ZI4Zwk7R-VH3sHST7U2xFfWoDtFPOv5UQXv1d2X2e7ULPxStoRU1KwJvV4EYvi82ZTX5dDfHcWrFOW8YZ3UBX_8DDuUj5zKcorRtW1JDU6DtETIxpBSt--OEgLrLUqVBlSzVmmVpePXQ_z2-hleANyugk9Gji3o2Pj3gBAdJaOHOjlwqpXln4729_zz9C2VQu_M</recordid><startdate>20040504</startdate><enddate>20040504</enddate><creator>Kalliomäki, T</creator><creator>Hill, R P</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20040504</creationdate><title>Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines</title><author>Kalliomäki, T ; Hill, R P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3986-febca580bc2facc2eb6d70b3408ffe4eaffcd2c77de09dc2e18058d6ea83f3c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>3-Iodobenzylguanidine - pharmacology</topic><topic>Acidification</topic><topic>Acidosis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cancer therapies</topic><topic>Cell Hypoxia - drug effects</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Experimental Therapeutics</topic><topic>Female</topic><topic>Fibrosarcoma</topic><topic>Fibrosarcoma - chemistry</topic><topic>Fibrosarcoma - drug therapy</topic><topic>Glucose</topic><topic>Glucose - pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hyperthermia</topic><topic>Hypoxia</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Melanoma</topic><topic>Melanoma, Experimental - chemistry</topic><topic>Melanoma, Experimental - drug therapy</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Molecular Medicine</topic><topic>Neoplasm Metastasis - pathology</topic><topic>Oncology</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalliomäki, T</creatorcontrib><creatorcontrib>Hill, R P</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalliomäki, T</au><au>Hill, R P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2004-05-04</date><risdate>2004</risdate><volume>90</volume><issue>9</issue><spage>1842</spage><epage>1849</epage><pages>1842-1849</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>In addition to hypoxia, acidic extracellular pH (pH
e
) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previous data have shown that exposure of murine tumour cells to acid conditions in culture can enhance their metastatic potential when injected subsequently into mice, raising the concern that deliberate tumour acidification might increase the probability of metastasis. In this study, we examined the effects of
in vivo
tumour acidification and hypoxia on the spontaneous metastatic potential of the murine KHT-C fibrosarcoma and B16F1 melanoma cell lines. A tumour-specific increase in extracellular acidity, demonstrated by measurements with pH electrodes, was achieved by daily intraperitoneal injections of meta-iodo-benzylguanidine (MIBG) and/or glucose. This method of tumour acidification during tumour growth did not significantly enhance the spontaneous metastatic potential of the two murine cell lines.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15150590</pmid><doi>10.1038/sj.bjc.6601766</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 2004-05, Vol.90 (9), p.1842-1849 |
| issn | 0007-0920 1532-1827 |
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| subjects | 3-Iodobenzylguanidine - pharmacology Acidification Acidosis Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Cell Hypoxia - drug effects Drug Resistance Epidemiology Experimental Therapeutics Female Fibrosarcoma Fibrosarcoma - chemistry Fibrosarcoma - drug therapy Glucose Glucose - pharmacology Hydrogen-Ion Concentration Hyperthermia Hypoxia Male Medical research Medical sciences Melanoma Melanoma, Experimental - chemistry Melanoma, Experimental - drug therapy Metastasis Mice Molecular Medicine Neoplasm Metastasis - pathology Oncology Tumor Cells, Cultured Tumors |
| title | Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines |
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