Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer

The predictive values of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) gene expressions were retrospectively evaluated in patients with gastric cancer treated by a regimen containing S-1. The study population consisted of 53 patients registered into different two phase II studi...

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Bibliographic Details
Published in:British journal of cancer 2004-10, Vol.91 (7), p.1245-1250
Main Authors: Ichikawa, W, Takahashi, T, Suto, K, Yamashita, T, Nihei, Z, Shirota, Y, Shimizu, M, Sasaki, Y, Hirayama, R
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antimetabolites, Antineoplastic - therapeutic use
Biomedical and Life Sciences
Biomedicine
Cancer Research
Clinical
Dihydrouracil Dehydrogenase (NADP) - analysis
Dihydrouracil Dehydrogenase (NADP) - biosynthesis
Drug Combinations
Drug Resistance
Epidemiology
Female
Gene Expression Profiling
Humans
Male
Middle Aged
Molecular Medicine
Neoplasm Metastasis
Oncology
Oxonic Acid - therapeutic use
Predictive Value of Tests
Prognosis
Pyridines - therapeutic use
Stomach Neoplasms - drug therapy
Stomach Neoplasms - enzymology
Stomach Neoplasms - genetics
Tegafur - therapeutic use
Thymidylate Synthase - analysis
Thymidylate Synthase - biosynthesis
Treatment Outcome
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Summary:The predictive values of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) gene expressions were retrospectively evaluated in patients with gastric cancer treated by a regimen containing S-1. The study population consisted of 53 patients registered into different two phase II studies for metastatic gastric cancer; 27 patients treated by S-1-alone study: 26 patients treated with S-1 combined with irinotecan (CPT-11). TS and DPD gene expressions in primary tumours were measured by the real-time reverse transcription PCR method. There was no statistical difference in DPD gene expression in terms of response in cases treated with S-1 alone and those treated with S-1 plus CPT-11. TS mRNA of responding tumours was lower than that of nonresponding ones when treated with S-1 ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6602139