Rapid Extragranular Plasticity in the Absence of Thalamocortical Plasticity in the Developing Primary Visual Cortex

Monocular deprivation during early postnatal development remodels the circuitry of the primary visual cortex so that most neurons respond poorly to stimuli presented to the deprived eye. This rapid physiological change is ultimately accompanied by a matching anatomical loss of input from the deprive...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2000-03, Vol.287 (5460), p.2029-2032
Main Authors: Trachtenberg, Joshua T., Trepel, Christopher, Stryker, Michael P.
Format: Article
Language:English
Subjects:
Adult stem cells
Animals
Artificial neural networks
Biological and medical sciences
Brain
Brain Mapping
Brain research
Cats
Cell growth
Computer networks
Control Groups
Developmental neurology
Electrodes
Eye and associated structures. Visual pathways and centers. Vision
Eyes
Eyes & eyesight
Fundamental and applied biological sciences. Psychology
Information networks
Kittens
Microelectrodes
monocular deprivation
Multipotent stem cells
Nervous system
Neural networks
Neural stem cells
Neuronal Plasticity
Neurons
Neurons - physiology
Ocular dominance
Photic Stimulation
Plasmids
Saddle points
Thalamus - anatomy & histology
Thalamus - growth & development
Thalamus - physiology
Vertebrates: nervous system and sense organs
Vision, Binocular
Vision, Monocular
Visual Cortex - anatomy & histology
Visual Cortex - growth & development
Visual Cortex - physiology
Visual Pathways - anatomy & histology
Visual Pathways - physiology
Visual Perception
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Description
Summary:Monocular deprivation during early postnatal development remodels the circuitry of the primary visual cortex so that most neurons respond poorly to stimuli presented to the deprived eye. This rapid physiological change is ultimately accompanied by a matching anatomical loss of input from the deprived eye. This remodeling is thought to be initiated at the thalamocortical synapse. Ocular dominance plasticity after brief (24 hours) monocular deprivation was analyzed by intrinsic signal optical imaging and by targeted extracellular unit recordings. Deprived-eye responsiveness was lost in the extragranular layers, whereas normal binocularity in layer IV was preserved. This finding supports the hypothesis that thalamocortical organization is guided by earlier changes at higher stages.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.287.5460.2029