Total exchangeable potassium in response to amiloride

The use of amiloride is described in twenty-four hypertensive patients who became hypokalaemic as a result of thiazide diuretic therapy in spite of oral potassium supplments. Amiloride caused a significant rise in exchangeable potassium, exchangeable potassium/kg body weight, and plasma potassium, t...

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Bibliographic Details
Published in:Postgraduate medical journal 1978-08, Vol.54 (634), p.533-537
Main Authors: Pearce, V. R., Antcliff, A. C., Beevers, D. G., Hamilton, M.
Format: Article
Language:English
Subjects:
Amiloride - therapeutic use
Body Weight
Carbon Dioxide - blood
Humans
Hypertension - drug therapy
Hypertension - metabolism
Hypokalemia - drug therapy
Potassium - metabolism
Pyrazines - therapeutic use
Time Factors
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Summary:The use of amiloride is described in twenty-four hypertensive patients who became hypokalaemic as a result of thiazide diuretic therapy in spite of oral potassium supplments. Amiloride caused a significant rise in exchangeable potassium, exchangeable potassium/kg body weight, and plasma potassium, together with a significant fall in plasma total carbon dioxide, body weight, systolic and diastolic blood pressures. These results suggest that amiloride has a useful role in this type of patient.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.54.634.533