Kidney biopsy in the hepatosplenic form of infection with Schistosoma mansoni in man

A study of early glomerular lesions was made in 8 patients infected with Schistosoma mansoni but having no clinical evidence of renal disease. Electron-microscopy of renal biopsies showed the presence of electron-dense deposits in basement membranes and of laminated bodies near the mesangial cells....

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Bibliographic Details
Published in:Bulletin of the World Health Organization 1970, Vol.42 (6), p.907-910
Main Authors: da Silva, L C, de Brito, T, Camargo, M E, de Boni, D R, Lopes, J D, Gunji, J
Format: Article
Language:English
Subjects:
Biopsy
Fluorescent Antibody Technique
Humans
Kidney - pathology
Kidney Diseases - pathology
Liver Diseases, Parasitic - pathology
Microscopy, Electron
Schistosomiasis - pathology
Splenic Diseases - pathology
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Summary:A study of early glomerular lesions was made in 8 patients infected with Schistosoma mansoni but having no clinical evidence of renal disease. Electron-microscopy of renal biopsies showed the presence of electron-dense deposits in basement membranes and of laminated bodies near the mesangial cells. Immunofluorescence showed that the deposits corresponded to IgG in 8 cases and to IgM in 2 cases. These lesions are comparable with those found in the kidneys of patients with cirrhosis of the liver.
ISSN:0042-9686