The origin of proteinuria at high altitude

Urinary protein excretion was measured before and after the intravenous infusion of lysine in 14 normal subjects after 4-6 days' acclimatization at 4846 m. Urinary albumin excretion before lysine was elevated in 11 subjects but alpha 1-microglobulin was detected in only four. After lysine a lar...

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Bibliographic Details
Published in:Postgraduate medical journal 1987-03, Vol.63 (737), p.179-181
Main Authors: Winterborn, M. H., Bradwell, A. R., Chesner, I. M., Jones, G. T.
Format: Article
Language:English
Subjects:
Acclimatization
Acetazolamide - pharmacology
Adult
Albuminuria - etiology
Albuminuria - physiopathology
Albuminuria - urine
Alpha-Globulins - urine
Altitude
Capillary Permeability
Humans
Kidney Glomerulus - blood supply
Kidney Glomerulus - physiopathology
Lysine
Male
Middle Aged
Proteinuria - etiology
Proteinuria - physiopathology
Proteinuria - urine
Space life sciences
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Summary:Urinary protein excretion was measured before and after the intravenous infusion of lysine in 14 normal subjects after 4-6 days' acclimatization at 4846 m. Urinary albumin excretion before lysine was elevated in 11 subjects but alpha 1-microglobulin was detected in only four. After lysine a large increase in albumin excretion occurred in all subjects. Together with the absence of alpha 1-microglobulin before lysine this implies that increased glomerular capillary permeability is the major cause of proteinuria after acclimatization to high altitude. The estimated minimum glomerular fluid albumin concentration was increased two to three fold above the published values in normal controls.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.63.737.179