Effect of treatment with botulinum toxin on spasticity

Botulinum toxin, a product of Clostridium botulinum, produces presynaptic neuromuscular block by preventing release of acetylcholine from nerve endings. The toxin was injected directly into the skeletal muscles of six patients with severe spasticity due to stroke-related hemiplegia. It produced both...

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Bibliographic Details
Published in:Postgraduate medical journal 1989-04, Vol.65 (762), p.208-210
Main Authors: Das, T. K., Park, D. M.
Format: Article
Language:English
Subjects:
Adult
Aged
Botulinum Toxins - administration & dosage
Botulinum Toxins - therapeutic use
Cerebrovascular Disorders - complications
Humans
Injections, Intramuscular
Middle Aged
Movement
Muscle Spasticity - drug therapy
Muscle Spasticity - etiology
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Summary:Botulinum toxin, a product of Clostridium botulinum, produces presynaptic neuromuscular block by preventing release of acetylcholine from nerve endings. The toxin was injected directly into the skeletal muscles of six patients with severe spasticity due to stroke-related hemiplegia. It produced both subjective and objective improvement. The toxin injections were well tolerated and no significant side effect was reported.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.65.762.208