Association of sarcoidosis, low-grade B-lymphoma and epidermoid carcinoma

We report on a case of the so-called sarcoidosis-lymphoma syndrome in a 65-years-old man diagnosed as having sarcoidosis and, four years later, neurosarcoidosis. The diagnoses of epidermoid carcinoma of the skin and of stage IV monocytoid, small cell lymphocytic lymphoma were made five and seven yea...

Full description

Saved in:
Bibliographic Details
Published in:Postgraduate medical journal 1997-09, Vol.73 (863), p.580-582
Main Authors: Romero, J., Ramón y Cajal, S., Vargas, J. A., Pérez-Maestu, R., Salas, C., Regueiro, C. A., Aragon, G.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - etiology
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - etiology
Male
Medical sciences
Middle Aged
Neoplasms, Second Primary - etiology
Sarcoidosis - complications
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Skin Neoplasms - etiology
Syndrome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report on a case of the so-called sarcoidosis-lymphoma syndrome in a 65-years-old man diagnosed as having sarcoidosis and, four years later, neurosarcoidosis. The diagnoses of epidermoid carcinoma of the skin and of stage IV monocytoid, small cell lymphocytic lymphoma were made five and seven years, respectively, after the initial diagnosis of sarcoidosis. It has been suggested that the increased mitotic activity of lymphocytes observed in sarcoidosis, favours their malignant transformation. Hypothetically, sarcoidosis might also influence the development of epidermoid carcinomas by depletion of circulating T4 lymphocytes and decreased resistance to oncogenic viruses that could lead to decreased tumour rejection in the epithelia exposed to carcinogenic stimuli.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.73.863.580