Serum prostate‐specific antigen levels in older men with or at risk of HIV infection

Objectives The aim of the study was to determine the rate of, and factors associated with, elevated prostate‐specific antigen (PSA) levels in older men with or at risk of HIV infection. Methods Using a cross‐sectional analysis, we interviewed 534 men ≥49 years old at risk for HIV infection on demogr...

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Bibliographic Details
Published in:HIV medicine 2006-10, Vol.7 (7), p.471-476
Main Authors: Vianna, LE, Lo, Y, Klein, RS
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
ageing
CD4 Lymphocyte Count
Cross-Sectional Studies
HIV Infections - blood
Human immunodeficiency virus
Humans
Male
men's health
Middle Aged
prostate
Prostate-Specific Antigen - blood
prostate‐specific antigen
Prostatic Neoplasms - prevention & control
Risk Factors
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Summary:Objectives The aim of the study was to determine the rate of, and factors associated with, elevated prostate‐specific antigen (PSA) levels in older men with or at risk of HIV infection. Methods Using a cross‐sectional analysis, we interviewed 534 men ≥49 years old at risk for HIV infection on demographics, behaviours and medical history. Laboratory testing included serum PSA level and HIV serology, and T‐cell subsets for those who were HIV seropositive. Elevated PSA level was defined as >4.0 ng/mL, and men with elevated PSA levels were referred for urological evaluation. Results Fifteen per cent of men were white, 55% black, and 23% Hispanic; median age was 53 years (range 49–80 years); 74% were sexually active; 65% currently smoked cigarettes; and 16% had taken androgens. Among 310 HIV‐positive men, CD4 counts were >500 cells/μL in 31%, 200–500 cells/μL in 51%, and
ISSN:1464-2662
1468-1293
DOI:10.1111/j.1468-1293.2006.00410.x