Human gene therapy vectors derived from feline lentiviruses

Lentiviral vectors are useful for gene transfer to dividing and nondividing cells. Feline immunodeficiency virus (FIV) vectors transduce most human cell types with good efficiency and may have advantages for clinical gene therapy applications. This article reviews significant progress in the develop...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 2008-05, Vol.123 (1), p.23-31
Main Authors: Barraza, Román A., Poeschla, Eric M.
Format: Article
Language:English
Subjects:
Animals
cat diseases
Cats
Feline immunodeficiency virus
Gene therapy
gene transfer
Genetic Therapy - methods
genetic transduction
Genetic Vectors - genetics
HIV Infections - therapy
Humans
immunity
Immunodeficiency Virus, Feline - genetics
Innate immunity
Lentivirus
literature reviews
Retroviral vectors
Transcription, Genetic
Transduction, Genetic
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Description
Summary:Lentiviral vectors are useful for gene transfer to dividing and nondividing cells. Feline immunodeficiency virus (FIV) vectors transduce most human cell types with good efficiency and may have advantages for clinical gene therapy applications. This article reviews significant progress in the development and refinement of FIV vector systems.
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2008.01.009