Shortening of cardiac action potential duration near an insulating boundary

It is known, from both experiments and simulations, that cardiac action potentials are shortened near a non-conducting boundary. In the present paper, this effect is studied in a simple, two-current ionic model, with propagation restricted to a 1D fibre. An asymptotic approximation for the dependenc...

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Bibliographic Details
Published in:Mathematical medicine and biology 2008-03, Vol.25 (1), p.21-36
Main Authors: Cain, John W., Schaeffer, David G.
Format: Article
Language:English
Subjects:
1D cable
action potential duration
Action Potentials
Animals
Anura
Computer Simulation
Electrophysiology
Heart - physiology
insulating boundary
Models, Cardiovascular
Myocardial Contraction
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Summary:It is known, from both experiments and simulations, that cardiac action potentials are shortened near a non-conducting boundary. In the present paper, this effect is studied in a simple, two-current ionic model, with propagation restricted to a 1D fibre. An asymptotic approximation for the dependence of action potential duration on distance to the boundary is derived. This estimate agrees well with simulations.
ISSN:1477-8599
1477-8602
DOI:10.1093/imammb/dqn002