The application of in vivo laser confocal microscopy to the diagnosis and evaluation of meibomian gland dysfunction

To evaluate the morphological changes of the meibomian glands (MG) in patients with meibomian gland dysfunction (MGD) compared to normal subjects by in vivo confocal microscopy and to investigate the relation of these changes to the clinical ocular surface findings and tear functions. Twenty MGD pat...

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Bibliographic Details
Published in:Molecular vision 2008-07, Vol.14, p.1263-1271
Main Authors: Matsumoto, Yukihiro, Sato, Enrique Adan, Ibrahim, Osama M A, Dogru, Murat, Tsubota, Kazuo
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Eye Diseases - diagnosis
Eye Diseases - pathology
Eye Diseases - physiopathology
Female
Humans
Male
Meibomian Glands - pathology
Meibomian Glands - physiopathology
Microscopy, Confocal
Middle Aged
Staining and Labeling
Tears - physiology
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Summary:To evaluate the morphological changes of the meibomian glands (MG) in patients with meibomian gland dysfunction (MGD) compared to normal subjects by in vivo confocal microscopy and to investigate the relation of these changes to the clinical ocular surface findings and tear functions. Twenty MGD patients and 15 normal subjects were recruited into this prospective study. Patients and controls underwent slit lamp examinations, tear film break-up time (BUT) measurements, fluorescein and Rose-Bengal stainings, Schirmer test I without anesthesia, tear evaporation rate assessment (TEROS), tear film lipid layer interferometry (DR-1), transillumination of the lids (meibography), MG expressibility test, and in vivo laser confocal microscopy of the lids (HRTII-RCM). The BUT, DR-1 tear film lipid layer interferometry grades, fluorescein and Rose-Bengal staining scores, MG drop out grade in meibography, and MG expressibility grades were significantly worse in MGD patients compared to normal controls (p
ISSN:1090-0535