Plasmid-encoded fosfomycin resistance

Fosfomycin ((-)-cis-1,2-epoxypropyl phosphonic acid) was discovered in 1968 as a secondary metabolite of several Streptomyces species. It aroused considerable interest, since it was a completely new molecule having antibacterial activity which exhibited relevant properties, such as a broad spectrum,...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 1991-05, Vol.35 (5), p.791-795
Main Authors: EVARISTO SUAREZ, J, CARMEN MENDOZA, M
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacteria - drug effects
Bacteria - genetics
Bacteriology
Biological and medical sciences
Drug Resistance, Microbial - genetics
Fosfomycin
Fosfomycin - pharmacology
Fundamental and applied biological sciences. Psychology
Genetics
Humans
Microbiology
Plasmids
Research Article
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Summary:Fosfomycin ((-)-cis-1,2-epoxypropyl phosphonic acid) was discovered in 1968 as a secondary metabolite of several Streptomyces species. It aroused considerable interest, since it was a completely new molecule having antibacterial activity which exhibited relevant properties, such as a broad spectrum, covering many pathogenic and opportunistic gram-positive (Staphylococcus aureus and Streptococcus spp.) and gram-negative (Pseudomonas aeruginosa, Neisseria spp., and members of the family Enterobacteriaceae) bacteria. The use of fosfomycin has selected another type of resistant organisms which actively incorporate the drug and have a fully sensitive enolpyruvyl transferase, indicating that their mechanism of resistance is different from that of the previously described mutants. They are usually multiresistant, can transfer their resistance through conjugation or transformation, and can be made susceptible through the use of curing agents, indicating a plasmid location for the Fo super(r) determinant.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.35.5.791