Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response

Summary CCR6 is expressed by multiple leucocyte subsets, including peripheral blood memory T cells, and mouse models implicate a role for this receptor in diverse inflammatory responses that include allergic airway disorders, inflammatory bowel disease and autoimmune encephalitis. In order to study...

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Bibliographic Details
Published in:Clinical and experimental immunology 2008-06, Vol.152 (3), p.440-447
Main Authors: Francis, J. N., Sabroe, I., Lloyd, C. M., Durham, S. R., Till, S. J.
Format: Article
Language:English
Subjects:
Adult
Allergens - immunology
allergy
Analytical, structural and metabolic biochemistry
Asthma - immunology
Biological and medical sciences
Bronchi - immunology
Bronchoalveolar Lavage Fluid - immunology
CCL20
CCR6
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cells, Cultured
Chemokine CCL20 - immunology
Chemokine CCL20 - metabolism
chemokine receptor
Chemotaxis, Leukocyte
Chronic obstructive pulmonary disease, asthma
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Molecular biophysics
Nasal Mucosa - immunology
Pneumology
Receptors, CCR6 - metabolism
Skin - immunology
T cells
T-Lymphocyte Subsets - immunology
Translational Studies
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Summary:Summary CCR6 is expressed by multiple leucocyte subsets, including peripheral blood memory T cells, and mouse models implicate a role for this receptor in diverse inflammatory responses that include allergic airway disorders, inflammatory bowel disease and autoimmune encephalitis. In order to study the role of CCR6 in humans, we have investigated the patterns of CCR6 expression and function on T cells from the peripheral blood, skin, nose and lung, in health and in allergic disease. Results show that CCR6 was expressed consistently on a higher proportion of tissue versus peripheral blood‐derived CD4+ T cells (P 
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2008.03657.x