Transduodenal excision of ampullary tumours

The commonly recommended treatment for ampullary tumours--pancreaticoduodenectomy results in significant morbidity and mortality. This study is a retrospective evaluation of the procedure of transduodenal local excision of ampullary tumours. Demographics, symptoms, histological findings and outcomes...

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Bibliographic Details
Published in:Ulster medical journal 2002-11, Vol.71 (2), p.121-127
Main Authors: Bohra, A K, McKie, L, Diamond, T
Format: Article
Language:English
Subjects:
Adenoma - pathology
Adenoma - surgery
Aged
Ampulla of Vater - pathology
Ampulla of Vater - surgery
Carcinoma - pathology
Carcinoma - surgery
Common Bile Duct Neoplasms - pathology
Common Bile Duct Neoplasms - surgery
Disease-Free Survival
Duodenum - surgery
Female
Humans
Male
Middle Aged
Pancreatectomy
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Retrospective Studies
Survival Analysis
Treatment Outcome
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Summary:The commonly recommended treatment for ampullary tumours--pancreaticoduodenectomy results in significant morbidity and mortality. This study is a retrospective evaluation of the procedure of transduodenal local excision of ampullary tumours. Demographics, symptoms, histological findings and outcomes were retrospectively analysed in 15 patients. Survival analysis was done by the method of Kaplan-Meier and log-rank test. The median age was 68 years (range 54-78). Endoscopic biopsy was accurate in only 41% of cases. CT scan demonstrated a mass in 50% cases. Definitive histology reported 4 adenomas, 2 carcinomas-in-situ and 9 adenocarcinomas. Median hospital stay was 13 days. There was no operative mortality. Mean duration of follow-up was 31 months (range 7-70 months). The procedure appears curative for adenomas and in-situ carcinoma. Overall 3 year actuarial survival for ampullary tumours is 65% while that for moderately differentiated carcinomas is 50%. Pre-operative investigations provide inadequate histological information. Wide local excision is a safe operation with low morbidity and good survival in carefully selected cases. However, the role of local excision for carcinoma appears to be palliative rather than curative.
ISSN:0041-6193