Comparison of the immune response of the rabbit to virulent and attenuated strains of type 1 poliovirus

Rabbits were immunized with the attenuated LSc, 2a(1)b or the virulent Mahoney strain of type 1 poliovirus, or with a partially purified preparation of the latter. It was found that the animals responded in a heterogeneous manner to antigens with a homogeneous virion population, such as LSc,2a(1)b a...

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Bibliographic Details
Published in:Bulletin of the World Health Organization 1974, Vol.50 (6), p.479-475
Main Authors: Gaudin, O G, Viac, J, Thouvenot, D, Sohier, R
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Antibodies, Viral - analysis
Antibody Formation
Antigens, Viral
Chromatography
Immunoglobulin G
Immunoglobulin M
Immunologic Techniques
Neutralization Tests
Poliovirus - immunology
Poliovirus Vaccine, Inactivated
Rabbits
Species Specificity
Vaccines, Attenuated
Virulence
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Summary:Rabbits were immunized with the attenuated LSc, 2a(1)b or the virulent Mahoney strain of type 1 poliovirus, or with a partially purified preparation of the latter. It was found that the animals responded in a heterogeneous manner to antigens with a homogeneous virion population, such as LSc,2a(1)b and, to a lesser extent, the partially purified Mahoney antigen. This heterogeneous immune response permits the preparation of specific antisera for intratypic serodifferentiation tests. However, the unpurified Mahoney strain, which has a heterogeneous virion population, induced a homogeneous immune response; all the antisera had a wide spectrum of antibodies and could not distinguish the wild from the attenuated strain. The differentiation capacity of the specific antisera was found to be linked to either the IgM or the IgG. The possible implications of these findings for human vaccination against poliomyelitis are discussed.
ISSN:0042-9686