Loading…
Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Scarification vaccination
Summary In this study, we evaluated the efficacy of vaccinia virus (VACV) containing mutations in the E3L virulence gene to protect mice against a lethal poxvirus challenge after vaccination by scarification. VACV strains with mutations in the E3L gene had significantly decreased pathogenicity, even...
Saved in:
| Published in: | Vaccine 2008-06, Vol.26 (23), p.2860-2872 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c609t-1053bcd80ea23a7823fe947d3943cec6a47914ea4c2bc3a04e97791247552e603 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c609t-1053bcd80ea23a7823fe947d3943cec6a47914ea4c2bc3a04e97791247552e603 |
| container_end_page | 2872 |
| container_issue | 23 |
| container_start_page | 2860 |
| container_title | Vaccine |
| container_volume | 26 |
| creator | Jentarra, Garilyn M Heck, Michael C Youn, Jin Won Kibler, Karen Langland, Jeffrey O Baskin, Carole R Ananieva, Olga Chang, Yung Jacobs, Bertram L |
| description | Summary In this study, we evaluated the efficacy of vaccinia virus (VACV) containing mutations in the E3L virulence gene to protect mice against a lethal poxvirus challenge after vaccination by scarification. VACV strains with mutations in the E3L gene had significantly decreased pathogenicity, even in immune deficient mice, yet retained the ability to produce a potent Th1-dominated immune response in mice after vaccination by scarification, while protecting against challenge with wild type, pathogenic VACV. Initial experiments were done using the mouse-adapted, neurovirulent Western Reserve (WR) strain of vaccinia virus. Testing of the full E3L deletion mutation in the Copenhagen and NYCBH strains of VACV, which are more appropriate for use in humans, produced similar results. These results suggest that highly attenuated strains of VACV containing mutations in E3L have the potential for use as scarification administered vaccines. |
| doi_str_mv | 10.1016/j.vaccine.2008.03.044 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2488381</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0264410X08003770</els_id><sourcerecordid>3419604071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c609t-1053bcd80ea23a7823fe947d3943cec6a47914ea4c2bc3a04e97791247552e603</originalsourceid><addsrcrecordid>eNqFkk2P0zAQhiMEYsvCTwBZQnAiZfyRxOGwCK2WD6kShwXEzZo6061LmgTbKdorvxy3jXZhL5xszTzz-h3PZNlTDnMOvHy9me_QWtfRXADoOcg5KHUvm3FdyVwUXN_PZiBKlSsO30-yRyFsAKCQvH6YnXCtikJoPst-fzuoOGQ758dAgf1ycc22Y8To-i4w17G4JnYhF-yKOmIY2NBH6qLDlnkaWmcPZG777UD7xCuGMZ0jRmrYZDK8YZcWvVtN9BQ_3B9nD1bYBnoynafZ1_cXX84_5ovPHz6dv1vktoQ65jyZX9pGA6GQWGkhV1SrqpG1kpZsiaqquSJUViytRFBUVykiVJVapRLkaXZ21B3G5ZYam6x6bM3g3Rb9tenRmX8znVubq35nhNJaap4EXk4Cvv85Uohm64KltsWO-jEYXle8kGWdwOd3wE0_-i41Z3hRaM1VJWSiiiNlfR-Cp9WNFQ5mP2OzMdP3mf2MDUiTZpzqnv3dx23VNNQEvJgADBbblcfOunDDCZBFLUuRuLdHjtKv7xx5E6yjzlLjPNlomt7918rZHQXbpmVKj_6gawq3XZsgDJjL_ULu9xE0gKwqkH8ATwDfGw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1558814723</pqid></control><display><type>article</type><title>Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Scarification vaccination</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Jentarra, Garilyn M ; Heck, Michael C ; Youn, Jin Won ; Kibler, Karen ; Langland, Jeffrey O ; Baskin, Carole R ; Ananieva, Olga ; Chang, Yung ; Jacobs, Bertram L</creator><creatorcontrib>Jentarra, Garilyn M ; Heck, Michael C ; Youn, Jin Won ; Kibler, Karen ; Langland, Jeffrey O ; Baskin, Carole R ; Ananieva, Olga ; Chang, Yung ; Jacobs, Bertram L</creatorcontrib><description>Summary In this study, we evaluated the efficacy of vaccinia virus (VACV) containing mutations in the E3L virulence gene to protect mice against a lethal poxvirus challenge after vaccination by scarification. VACV strains with mutations in the E3L gene had significantly decreased pathogenicity, even in immune deficient mice, yet retained the ability to produce a potent Th1-dominated immune response in mice after vaccination by scarification, while protecting against challenge with wild type, pathogenic VACV. Initial experiments were done using the mouse-adapted, neurovirulent Western Reserve (WR) strain of vaccinia virus. Testing of the full E3L deletion mutation in the Copenhagen and NYCBH strains of VACV, which are more appropriate for use in humans, produced similar results. These results suggest that highly attenuated strains of VACV containing mutations in E3L have the potential for use as scarification administered vaccines.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2008.03.044</identifier><identifier>PMID: 18455281</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Intranasal ; Allergy and Immunology ; Animals ; Antibodies, Viral - analysis ; Antibodies, Viral - biosynthesis ; Antiviral Agents - pharmacology ; Applied microbiology ; Biological and medical sciences ; Cells, Cultured ; Comet Assay ; Cricetinae ; Cytokines - biosynthesis ; Drug Resistance, Viral - genetics ; E3L ; Female ; Fundamental and applied biological sciences. Psychology ; Genes, Viral - genetics ; Genes, Viral - immunology ; Immune response ; Immunity, Cellular - immunology ; Interferons - pharmacology ; Kinases ; Laboratories ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, SCID ; Microbiology ; Mutation ; Mutation - genetics ; Mutation - immunology ; Neutralization Tests ; Pathogens ; Poxvirus ; Rabbits ; Smallpox ; Smallpox vaccine ; Spleen - cytology ; Spleen - immunology ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Attenuated - administration & dosage ; Vaccines, Attenuated - genetics ; Vaccines, Attenuated - immunology ; Vaccinia ; Vaccinia - immunology ; Vaccinia - prevention & control ; Vaccinia virus ; Vaccinia virus - genetics ; Viral Vaccines - administration & dosage ; Viral Vaccines - genetics ; Viral Vaccines - immunology ; Virus Replication</subject><ispartof>Vaccine, 2008-06, Vol.26 (23), p.2860-2872</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jun 2, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-1053bcd80ea23a7823fe947d3943cec6a47914ea4c2bc3a04e97791247552e603</citedby><cites>FETCH-LOGICAL-c609t-1053bcd80ea23a7823fe947d3943cec6a47914ea4c2bc3a04e97791247552e603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20359362$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18455281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jentarra, Garilyn M</creatorcontrib><creatorcontrib>Heck, Michael C</creatorcontrib><creatorcontrib>Youn, Jin Won</creatorcontrib><creatorcontrib>Kibler, Karen</creatorcontrib><creatorcontrib>Langland, Jeffrey O</creatorcontrib><creatorcontrib>Baskin, Carole R</creatorcontrib><creatorcontrib>Ananieva, Olga</creatorcontrib><creatorcontrib>Chang, Yung</creatorcontrib><creatorcontrib>Jacobs, Bertram L</creatorcontrib><title>Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Scarification vaccination</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Summary In this study, we evaluated the efficacy of vaccinia virus (VACV) containing mutations in the E3L virulence gene to protect mice against a lethal poxvirus challenge after vaccination by scarification. VACV strains with mutations in the E3L gene had significantly decreased pathogenicity, even in immune deficient mice, yet retained the ability to produce a potent Th1-dominated immune response in mice after vaccination by scarification, while protecting against challenge with wild type, pathogenic VACV. Initial experiments were done using the mouse-adapted, neurovirulent Western Reserve (WR) strain of vaccinia virus. Testing of the full E3L deletion mutation in the Copenhagen and NYCBH strains of VACV, which are more appropriate for use in humans, produced similar results. These results suggest that highly attenuated strains of VACV containing mutations in E3L have the potential for use as scarification administered vaccines.</description><subject>Administration, Intranasal</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies, Viral - analysis</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Antiviral Agents - pharmacology</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Comet Assay</subject><subject>Cricetinae</subject><subject>Cytokines - biosynthesis</subject><subject>Drug Resistance, Viral - genetics</subject><subject>E3L</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Viral - genetics</subject><subject>Genes, Viral - immunology</subject><subject>Immune response</subject><subject>Immunity, Cellular - immunology</subject><subject>Interferons - pharmacology</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, SCID</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Mutation - genetics</subject><subject>Mutation - immunology</subject><subject>Neutralization Tests</subject><subject>Pathogens</subject><subject>Poxvirus</subject><subject>Rabbits</subject><subject>Smallpox</subject><subject>Smallpox vaccine</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Attenuated - administration & dosage</subject><subject>Vaccines, Attenuated - genetics</subject><subject>Vaccines, Attenuated - immunology</subject><subject>Vaccinia</subject><subject>Vaccinia - immunology</subject><subject>Vaccinia - prevention & control</subject><subject>Vaccinia virus</subject><subject>Vaccinia virus - genetics</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - genetics</subject><subject>Viral Vaccines - immunology</subject><subject>Virus Replication</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkk2P0zAQhiMEYsvCTwBZQnAiZfyRxOGwCK2WD6kShwXEzZo6061LmgTbKdorvxy3jXZhL5xszTzz-h3PZNlTDnMOvHy9me_QWtfRXADoOcg5KHUvm3FdyVwUXN_PZiBKlSsO30-yRyFsAKCQvH6YnXCtikJoPst-fzuoOGQ758dAgf1ycc22Y8To-i4w17G4JnYhF-yKOmIY2NBH6qLDlnkaWmcPZG777UD7xCuGMZ0jRmrYZDK8YZcWvVtN9BQ_3B9nD1bYBnoynafZ1_cXX84_5ovPHz6dv1vktoQ65jyZX9pGA6GQWGkhV1SrqpG1kpZsiaqquSJUViytRFBUVykiVJVapRLkaXZ21B3G5ZYam6x6bM3g3Rb9tenRmX8znVubq35nhNJaap4EXk4Cvv85Uohm64KltsWO-jEYXle8kGWdwOd3wE0_-i41Z3hRaM1VJWSiiiNlfR-Cp9WNFQ5mP2OzMdP3mf2MDUiTZpzqnv3dx23VNNQEvJgADBbblcfOunDDCZBFLUuRuLdHjtKv7xx5E6yjzlLjPNlomt7918rZHQXbpmVKj_6gawq3XZsgDJjL_ULu9xE0gKwqkH8ATwDfGw</recordid><startdate>20080602</startdate><enddate>20080602</enddate><creator>Jentarra, Garilyn M</creator><creator>Heck, Michael C</creator><creator>Youn, Jin Won</creator><creator>Kibler, Karen</creator><creator>Langland, Jeffrey O</creator><creator>Baskin, Carole R</creator><creator>Ananieva, Olga</creator><creator>Chang, Yung</creator><creator>Jacobs, Bertram L</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20080602</creationdate><title>Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Scarification vaccination</title><author>Jentarra, Garilyn M ; Heck, Michael C ; Youn, Jin Won ; Kibler, Karen ; Langland, Jeffrey O ; Baskin, Carole R ; Ananieva, Olga ; Chang, Yung ; Jacobs, Bertram L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-1053bcd80ea23a7823fe947d3943cec6a47914ea4c2bc3a04e97791247552e603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Intranasal</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies, Viral - analysis</topic><topic>Antibodies, Viral - biosynthesis</topic><topic>Antiviral Agents - pharmacology</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Comet Assay</topic><topic>Cricetinae</topic><topic>Cytokines - biosynthesis</topic><topic>Drug Resistance, Viral - genetics</topic><topic>E3L</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Viral - genetics</topic><topic>Genes, Viral - immunology</topic><topic>Immune response</topic><topic>Immunity, Cellular - immunology</topic><topic>Interferons - pharmacology</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, SCID</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Mutation - genetics</topic><topic>Mutation - immunology</topic><topic>Neutralization Tests</topic><topic>Pathogens</topic><topic>Poxvirus</topic><topic>Rabbits</topic><topic>Smallpox</topic><topic>Smallpox vaccine</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, Attenuated - administration & dosage</topic><topic>Vaccines, Attenuated - genetics</topic><topic>Vaccines, Attenuated - immunology</topic><topic>Vaccinia</topic><topic>Vaccinia - immunology</topic><topic>Vaccinia - prevention & control</topic><topic>Vaccinia virus</topic><topic>Vaccinia virus - genetics</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Viral Vaccines - genetics</topic><topic>Viral Vaccines - immunology</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jentarra, Garilyn M</creatorcontrib><creatorcontrib>Heck, Michael C</creatorcontrib><creatorcontrib>Youn, Jin Won</creatorcontrib><creatorcontrib>Kibler, Karen</creatorcontrib><creatorcontrib>Langland, Jeffrey O</creatorcontrib><creatorcontrib>Baskin, Carole R</creatorcontrib><creatorcontrib>Ananieva, Olga</creatorcontrib><creatorcontrib>Chang, Yung</creatorcontrib><creatorcontrib>Jacobs, Bertram L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jentarra, Garilyn M</au><au>Heck, Michael C</au><au>Youn, Jin Won</au><au>Kibler, Karen</au><au>Langland, Jeffrey O</au><au>Baskin, Carole R</au><au>Ananieva, Olga</au><au>Chang, Yung</au><au>Jacobs, Bertram L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Scarification vaccination</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2008-06-02</date><risdate>2008</risdate><volume>26</volume><issue>23</issue><spage>2860</spage><epage>2872</epage><pages>2860-2872</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Summary In this study, we evaluated the efficacy of vaccinia virus (VACV) containing mutations in the E3L virulence gene to protect mice against a lethal poxvirus challenge after vaccination by scarification. VACV strains with mutations in the E3L gene had significantly decreased pathogenicity, even in immune deficient mice, yet retained the ability to produce a potent Th1-dominated immune response in mice after vaccination by scarification, while protecting against challenge with wild type, pathogenic VACV. Initial experiments were done using the mouse-adapted, neurovirulent Western Reserve (WR) strain of vaccinia virus. Testing of the full E3L deletion mutation in the Copenhagen and NYCBH strains of VACV, which are more appropriate for use in humans, produced similar results. These results suggest that highly attenuated strains of VACV containing mutations in E3L have the potential for use as scarification administered vaccines.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18455281</pmid><doi>10.1016/j.vaccine.2008.03.044</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2008-06, Vol.26 (23), p.2860-2872 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2488381 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Administration, Intranasal Allergy and Immunology Animals Antibodies, Viral - analysis Antibodies, Viral - biosynthesis Antiviral Agents - pharmacology Applied microbiology Biological and medical sciences Cells, Cultured Comet Assay Cricetinae Cytokines - biosynthesis Drug Resistance, Viral - genetics E3L Female Fundamental and applied biological sciences. Psychology Genes, Viral - genetics Genes, Viral - immunology Immune response Immunity, Cellular - immunology Interferons - pharmacology Kinases Laboratories Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, SCID Microbiology Mutation Mutation - genetics Mutation - immunology Neutralization Tests Pathogens Poxvirus Rabbits Smallpox Smallpox vaccine Spleen - cytology Spleen - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Vaccinia Vaccinia - immunology Vaccinia - prevention & control Vaccinia virus Vaccinia virus - genetics Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology Virus Replication |
| title | Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Scarification vaccination |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T12%3A33%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vaccinia%20viruses%20with%20mutations%20in%20the%20E3L%20gene%20as%20potential%20replication-competent,%20attenuated%20vaccines:%20Scarification%20vaccination&rft.jtitle=Vaccine&rft.au=Jentarra,%20Garilyn%20M&rft.date=2008-06-02&rft.volume=26&rft.issue=23&rft.spage=2860&rft.epage=2872&rft.pages=2860-2872&rft.issn=0264-410X&rft.eissn=1873-2518&rft.coden=VACCDE&rft_id=info:doi/10.1016/j.vaccine.2008.03.044&rft_dat=%3Cproquest_pubme%3E3419604071%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c609t-1053bcd80ea23a7823fe947d3943cec6a47914ea4c2bc3a04e97791247552e603%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1558814723&rft_id=info:pmid/18455281&rfr_iscdi=true |