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Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs
Abstract We evaluated virus-specific B and T cell responses induced by the attenuated Wa (P1A[8]G1) human rotavirus (AttHRV) oral 2-dose vaccine with or without Lactobacillus acidophilus (LA) colonization in neonatal gnotobiotic (Gn) pigs. The AttHRV vaccinated and LA-fed pigs had a significantly hi...
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| Published in: | Vaccine 2008-07, Vol.26 (29), p.3655-3661 |
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| cites | cdi_FETCH-LOGICAL-c614t-afd117a899c56c9cb0df3f8af31813f67e16912907298cbe80ab36cd975b6b483 |
| container_end_page | 3661 |
| container_issue | 29 |
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| container_title | Vaccine |
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| creator | Zhang, Wei Azevedo, Marli S.P Wen, Ke Gonzalez, Ana Saif, Linda J Li, Guohua Yousef, Ahmed E Yuan, Lijuan |
| description | Abstract We evaluated virus-specific B and T cell responses induced by the attenuated Wa (P1A[8]G1) human rotavirus (AttHRV) oral 2-dose vaccine with or without Lactobacillus acidophilus (LA) colonization in neonatal gnotobiotic (Gn) pigs. The AttHRV vaccinated and LA-fed pigs had a significantly higher magnitude of HRV-specific IFN-γ producing CD8+ T cell responses in ileum and spleen, IgA and IgG antibody-secreting cell responses in ileum, and serum IgM, IgA and IgG antibody and virus neutralizing antibody titers compared to the AttHRV vaccinated pigs without LA colonization. These findings suggest that L. acidophilus has significant immunopotentiating effects and may be used as a safe oral adjuvant for rotavirus vaccines in neonates. |
| doi_str_mv | 10.1016/j.vaccine.2008.04.070 |
| format | article |
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The AttHRV vaccinated and LA-fed pigs had a significantly higher magnitude of HRV-specific IFN-γ producing CD8+ T cell responses in ileum and spleen, IgA and IgG antibody-secreting cell responses in ileum, and serum IgM, IgA and IgG antibody and virus neutralizing antibody titers compared to the AttHRV vaccinated pigs without LA colonization. These findings suggest that L. acidophilus has significant immunopotentiating effects and may be used as a safe oral adjuvant for rotavirus vaccines in neonates.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2008.04.070</identifier><identifier>PMID: 18524434</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Oral ; Allergy and Immunology ; Animals ; Applied microbiology ; B and T cell immune responses to rotavirus vaccine ; B-Lymphocytes - immunology ; Bacteriology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Germ-Free Life ; Gnotobiotic pigs ; Human rotavirus ; Humans ; Ileum - immunology ; Immunization, Secondary ; Immunoglobulin A - immunology ; Immunoglobulin G - immunology ; Immunoglobulin M ; Immunologic Factors - pharmacology ; Interferon-gamma - secretion ; Lactobacillus acidophilus ; Lactobacillus acidophilus - immunology ; Microbiology ; Miscellaneous ; Neutralization Tests ; Probiotic Lactobacillus ; Probiotics - pharmacology ; Rotavirus Vaccines - administration & dosage ; Rotavirus Vaccines - immunology ; Spleen - immunology ; Swine ; T-Lymphocytes - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Attenuated - administration & dosage ; Vaccines, Attenuated - immunology ; Virology</subject><ispartof>Vaccine, 2008-07, Vol.26 (29), p.3655-3661</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c614t-afd117a899c56c9cb0df3f8af31813f67e16912907298cbe80ab36cd975b6b483</citedby><cites>FETCH-LOGICAL-c614t-afd117a899c56c9cb0df3f8af31813f67e16912907298cbe80ab36cd975b6b483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20480002$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18524434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Azevedo, Marli S.P</creatorcontrib><creatorcontrib>Wen, Ke</creatorcontrib><creatorcontrib>Gonzalez, Ana</creatorcontrib><creatorcontrib>Saif, Linda J</creatorcontrib><creatorcontrib>Li, Guohua</creatorcontrib><creatorcontrib>Yousef, Ahmed E</creatorcontrib><creatorcontrib>Yuan, Lijuan</creatorcontrib><title>Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract We evaluated virus-specific B and T cell responses induced by the attenuated Wa (P1A[8]G1) human rotavirus (AttHRV) oral 2-dose vaccine with or without Lactobacillus acidophilus (LA) colonization in neonatal gnotobiotic (Gn) pigs. The AttHRV vaccinated and LA-fed pigs had a significantly higher magnitude of HRV-specific IFN-γ producing CD8+ T cell responses in ileum and spleen, IgA and IgG antibody-secreting cell responses in ileum, and serum IgM, IgA and IgG antibody and virus neutralizing antibody titers compared to the AttHRV vaccinated pigs without LA colonization. These findings suggest that L. acidophilus has significant immunopotentiating effects and may be used as a safe oral adjuvant for rotavirus vaccines in neonates.</description><subject>Administration, Oral</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Applied microbiology</subject><subject>B and T cell immune responses to rotavirus vaccine</subject><subject>B-Lymphocytes - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Germ-Free Life</subject><subject>Gnotobiotic pigs</subject><subject>Human rotavirus</subject><subject>Humans</subject><subject>Ileum - immunology</subject><subject>Immunization, Secondary</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M</subject><subject>Immunologic Factors - pharmacology</subject><subject>Interferon-gamma - secretion</subject><subject>Lactobacillus acidophilus</subject><subject>Lactobacillus acidophilus - immunology</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Neutralization Tests</subject><subject>Probiotic Lactobacillus</subject><subject>Probiotics - pharmacology</subject><subject>Rotavirus Vaccines - administration & dosage</subject><subject>Rotavirus Vaccines - immunology</subject><subject>Spleen - immunology</subject><subject>Swine</subject><subject>T-Lymphocytes - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Attenuated - administration & dosage</subject><subject>Vaccines, Attenuated - immunology</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkluP0zAQhSMEYsvCTwDlBcRLy_gSx35ZhFbcpEogARJvluM47ZTU7tpJpf57HDUslwf2ySP5m5ljn1MUTwmsCBDxarc6GmvRuxUFkCvgK6jhXrEgsmZLWhF5v1gAFXzJCXy_KB6ltAOAihH1sLggsqKcM74oDp9jaDAMaMu1sUNojMW-H1OZzzYctjjVzm-Nty6Vw9aVuN-PPmycR4vDqQxdaXwZounLGAZzxJgbZmkl-nLjw_BrwwE36XHxoDN9ck_m87L49u7t1-sPy_Wn9x-v36yXVhA-LE3XElIbqZSthFW2gbZjnTQdI5KwTtSOCEWogpoqaRsnwTRM2FbVVSMaLtllcXWeexibvWut80PWqA8R9yaedDCo_77xuNWbcNSUK1JVKg94MQ-I4WZ0adB7TNb1vfEujEkLRXneT-4Eiao5E4Jl8OX_wQqglpKSCa3OqI0hpei6W-EE9OS_3un5k_Xkvwaus_-579mfr_7dNRuegeczYJI1fRezsZhuOQpc5pjQzL0-cy57dEQXdbLocghajM4Oug14p5SrfybYHnNoTP_DnVzahTH6HABNdKIa9JcprFNWIQuocsF-Am2l6NQ</recordid><startdate>20080704</startdate><enddate>20080704</enddate><creator>Zhang, Wei</creator><creator>Azevedo, Marli S.P</creator><creator>Wen, Ke</creator><creator>Gonzalez, Ana</creator><creator>Saif, Linda J</creator><creator>Li, Guohua</creator><creator>Yousef, Ahmed E</creator><creator>Yuan, Lijuan</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7QO</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080704</creationdate><title>Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs</title><author>Zhang, Wei ; Azevedo, Marli S.P ; Wen, Ke ; Gonzalez, Ana ; Saif, Linda J ; Li, Guohua ; Yousef, Ahmed E ; Yuan, Lijuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c614t-afd117a899c56c9cb0df3f8af31813f67e16912907298cbe80ab36cd975b6b483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Administration, Oral</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Applied microbiology</topic><topic>B and T cell immune responses to rotavirus vaccine</topic><topic>B-Lymphocytes - immunology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Germ-Free Life</topic><topic>Gnotobiotic pigs</topic><topic>Human rotavirus</topic><topic>Humans</topic><topic>Ileum - immunology</topic><topic>Immunization, Secondary</topic><topic>Immunoglobulin A - immunology</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M</topic><topic>Immunologic Factors - pharmacology</topic><topic>Interferon-gamma - secretion</topic><topic>Lactobacillus acidophilus</topic><topic>Lactobacillus acidophilus - immunology</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Neutralization Tests</topic><topic>Probiotic Lactobacillus</topic><topic>Probiotics - pharmacology</topic><topic>Rotavirus Vaccines - administration & dosage</topic><topic>Rotavirus Vaccines - immunology</topic><topic>Spleen - immunology</topic><topic>Swine</topic><topic>T-Lymphocytes - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, Attenuated - administration & dosage</topic><topic>Vaccines, Attenuated - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Azevedo, Marli S.P</creatorcontrib><creatorcontrib>Wen, Ke</creatorcontrib><creatorcontrib>Gonzalez, Ana</creatorcontrib><creatorcontrib>Saif, Linda J</creatorcontrib><creatorcontrib>Li, Guohua</creatorcontrib><creatorcontrib>Yousef, Ahmed E</creatorcontrib><creatorcontrib>Yuan, Lijuan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Wei</au><au>Azevedo, Marli S.P</au><au>Wen, Ke</au><au>Gonzalez, Ana</au><au>Saif, Linda J</au><au>Li, Guohua</au><au>Yousef, Ahmed E</au><au>Yuan, Lijuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2008-07-04</date><risdate>2008</risdate><volume>26</volume><issue>29</issue><spage>3655</spage><epage>3661</epage><pages>3655-3661</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract We evaluated virus-specific B and T cell responses induced by the attenuated Wa (P1A[8]G1) human rotavirus (AttHRV) oral 2-dose vaccine with or without Lactobacillus acidophilus (LA) colonization in neonatal gnotobiotic (Gn) pigs. The AttHRV vaccinated and LA-fed pigs had a significantly higher magnitude of HRV-specific IFN-γ producing CD8+ T cell responses in ileum and spleen, IgA and IgG antibody-secreting cell responses in ileum, and serum IgM, IgA and IgG antibody and virus neutralizing antibody titers compared to the AttHRV vaccinated pigs without LA colonization. These findings suggest that L. acidophilus has significant immunopotentiating effects and may be used as a safe oral adjuvant for rotavirus vaccines in neonates.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18524434</pmid><doi>10.1016/j.vaccine.2008.04.070</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Oral Allergy and Immunology Animals Applied microbiology B and T cell immune responses to rotavirus vaccine B-Lymphocytes - immunology Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Germ-Free Life Gnotobiotic pigs Human rotavirus Humans Ileum - immunology Immunization, Secondary Immunoglobulin A - immunology Immunoglobulin G - immunology Immunoglobulin M Immunologic Factors - pharmacology Interferon-gamma - secretion Lactobacillus acidophilus Lactobacillus acidophilus - immunology Microbiology Miscellaneous Neutralization Tests Probiotic Lactobacillus Probiotics - pharmacology Rotavirus Vaccines - administration & dosage Rotavirus Vaccines - immunology Spleen - immunology Swine T-Lymphocytes - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Virology |
| title | Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs |
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